描述
1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt)
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 100 μg (with stopper and crimp cap (850149P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850149P-500ug))
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]
一般描述
磷脂酰肌醇(PI)是一种磷脂，占真核细胞总脂质的10%。18:1 PI（1,2-二油酰基-sn-甘油-3-磷酸-(1′-肌肌醇)/DOPI）是一种阴离子型磷脂。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。
应用
18:1 PI（1,2-二油酰基-sn-甘油-3-磷酸-(1′-肌肌醇)/DOPI）已用于制备混合脂质巨型单室囊泡(LM-GUV)。
生化/生理作用
磷脂酰肌醇(PI)可作为前体，生成水溶性磷酸肌醇。18:1 PI（1,2-二油酰基-sn-甘油-3-磷酸-(1′-肌肌醇)/DOPI）可作为溶酶体磷脂酶A2(LPLA2)的底物，并促进其活性。
包装
带塞子和压接盖的2 mL棕色血清瓶（850149P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850149P-500ug）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
Inositol Phosphate Metabolism
Cellular and Molecular Mechanisms of Inflammation, 153-174 (1992)
Akira Abe et al.
Journal of lipid research, 50(10), 2027-2035 (2009-03-27)
Lysosomal phospholipase A2 (LPLA2) is characterized by increased activity toward zwitterionic phospholipid liposomes containing negatively charged lipids under acidic conditions. The effect of anionic lipids on LPLA2 activity was investigated. Mouse LPLA2 activity was assayed as C2-ceramide transacylation. Sulfatide incorporated
Betsy B McIntosh et al.
Current biology : CB, 28(2), 236-248 (2018-01-18)
Microtubule and actin filament molecular motors such as kinesin-1 and myosin-Ic (Myo1c) transport and remodel membrane-bound vesicles; however, it is unclear how they coordinate to accomplish these tasks. We introduced kinesin-1- and Myo1c-bound giant unilamellar vesicles (GUVs) into a micropatterned
Michael Margolis et al.
Biochimie, 108, 133-139 (2014-12-03)
Obesity, an established risk factor for breast cancer (BC), is associated with systemic inflammation. The breast contains adipose tissue (bAT), yet whether it plays a role in BC progression in obese females is being intensively studied. There is scarce knowledge
Natalia Rueda-Rincon et al.
Oncotarget, 6(25), 21240-21254 (2015-06-11)
The p53 tumor suppressor is the central component of a complex network of signaling pathways that protect organisms against the propagation of cells carrying oncogenic mutations. Here we report a previously unrecognized role of p53 in membrane phospholipids composition. By
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