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描述
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (ammonium salt)
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 100 μg (with stopper and crimp cap (850144P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850144P-500ug))
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](O)[C@@H]1O)OP(OC[C@H](OC([C19H31])=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])=O.[NH4+]
一般描述
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。
应用
18:0-20:4 PI 或 1-硬脂酰-2-花生四烯酰-sn-甘油-3-磷酸肌醇（铵盐）已用于：
- 作为阴性对照，通过表面等离子共振（SPR） 实验评估硫酸胆固醇与受体 Mincle 之间相互作用的特异性
- 作为脂质体中的测试脂质，包含在骨髓细胞 2（TREM2）配体上表达的候选触发受体，以评估 TREM2 刺激
- 作为液相色谱串联质谱（LC-MS/MS）分析的参考，以鉴定癌症组织源球体（CTOS）提取物中的 PI(18:0/20:4)
包装
带塞子和压接盖的2 mL棕色血清瓶（850144P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850144P-500ug）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Takanori Hiraide et al.
Scientific reports, 6, 29935-29935 (2016-07-21)
Accumulating evidence indicates that cancer cells show specific alterations in phospholipid metabolism that contribute to tumour progression in several types of cancer, including colorectal cancer. Questions still remain as to what lipids characterize the outer edge of cancer tissues and
Alexey V Kostarnoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2758-E2765 (2017-03-16)
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation;
Alicia A Nugent et al.
Neuron, 105(5), 837-854 (2020-01-07)
Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms and cell sorting with RNA
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
Annemieke de Jong et al.
Nature immunology, 15(2), 177-185 (2013-12-24)
T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we
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