检测方案
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
形式
powder
包装
pkg of 1 × 100 μg (with stopper and crimp cap (850104P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850104P-500ug))
制造商/商品名称
Avanti Research™ - A Croda Brand 850104P
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]
一般描述
溶血磷脂酰肌醇(LPI)是头基为肌醇的酸性溶血磷脂。
应用
18:0 Lyso PI或(1-硬脂酰-2-羟基-sn-甘油-3-磷酸肌醇)已用作溶血磷脂酰肌醇(LPI)的底物，在溶血磷脂酰肌醇酰基转移酶生化分析中测定肝脏微粒体的溶血磷脂酰肌醇酰基转移酶(LPIAT)活性。作为人工合成的LPI，它可与肝脏LPI比较其在转铁蛋白(Tf)内吞中的作用。它还用作去势大鼠的血清LPI水平定量分析的LPI标准品。
生化/生理作用
L-α-溶血磷脂酰肌醇（LPI）循环水平的升高与癌症相关，而且LPI是G蛋白偶联受体GPR55的有效配体。
溶血磷脂酰肌醇(LPI)具有丝裂原活性，可用作生物活性溶血磷脂介质。它可作为脂质介质。
包装
带塞子和压接盖的2 mL棕色血清瓶（850104P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850104P-500ug）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Monica Imbernon et al.
Molecular and cellular endocrinology, 383(1-2), 159-169 (2014-01-01)
The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with obesity in humans. We have investigated the regulation of GPR55 in rat white adipose tissue (WAT) in different physiological and pathophysiological settings involved in energy
Robert N Helsley et al.
eLife, 8 (2019-10-18)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-related cirrhosis, and
Saori Oka et al.
Biochemical and biophysical research communications, 362(4), 928-934 (2007-09-04)
GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably
Mariachiara Bianco et al.
Food chemistry, 324, 126878-126878 (2020-04-29)
Ceramides (Cer) and cerebrosides are important sphingolipids (SL) involved in many biological processes. Herein, the SL content of yellow lupin seeds (Lupinus luteus) was determined by liquid-liquid extraction, mild alkaline hydrolysis (1 h at 37 °C) and reversed-phase liquid chromatography with negative
Ieva Ailte et al.
Traffic (Copenhagen, Denmark), 18(3), 176-191 (2017-01-10)
In this study, we have investigated how clathrin-dependent endocytosis is affected by exogenously added lysophospholipids (LPLs). Addition of LPLs with large head groups strongly inhibits transferrin (Tf) endocytosis in various cell lines, while LPLs with small head groups do not.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门