检测方案
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
形式
powder
包装
pkg of 1 × 100 μg (with stopper and crimp cap (850102P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850102P-500ug))
制造商/商品名称
Avanti Research™ - A Croda Brand 850102P
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]
一般描述
溶血磷脂酰肌醇（LPI）是一种生物活性脂质。
应用
16:0 Lyso PI（1-棕榈酰基-2-羟基-sn-甘油-3-磷酸肌醇）已被用作脂质标准品，用于优化液相色谱-质谱（LC-MS）方法条件，并且在溶血磷脂酰肌醇酰基转移酶生化分析中用作溶血磷脂酰肌醇（LPI）底物，以测定肝微粒体的溶血磷脂酰肌醇酰基转移酶（LPIAT）活性。它也可以用作合成的LPI，以比较其在转铁蛋白（Tf）介导的内吞作用下与肝脏LPI的效应。
生化/生理作用
L-α-溶血磷脂酰肌醇（LPI）循环水平的升高与癌症相关，而且LPI是G蛋白偶联受体GPR55的有效配体。
溶血磷脂酰肌醇（LPI）具有调节癌症迁移的能力。它可以控制内皮细胞的功能。LPI可以作为细胞生长的自分泌调节剂，因此已知其参与癌症的进展。它可以刺激信号级联反应，这对于细胞的存活、迁移和增殖至关重要。
包装
带塞子和压接盖的2 mL棕色血清瓶（850102P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850102P-500ug）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Emily L Ruban et al.
Biochemical Society transactions, 42(5), 1372-1377 (2014-09-19)
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the
Robert N Helsley et al.
eLife, 8 (2019-10-18)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-related cirrhosis, and
Ieva Ailte et al.
Traffic (Copenhagen, Denmark), 18(3), 176-191 (2017-01-10)
In this study, we have investigated how clathrin-dependent endocytosis is affected by exogenously added lysophospholipids (LPLs). Addition of LPLs with large head groups strongly inhibits transferrin (Tf) endocytosis in various cell lines, while LPLs with small head groups do not.
Roberto Piñeiro et al.
Biochimica et biophysica acta, 1821(4), 694-705 (2012-01-31)
Lysophosphatidylinositol (LPI) is a bioactive lipid generated by phospholipase A2 which is believed to play an important role in several diseases. Indeed LPI can affect various functions such as cell growth, differentiation and motility, in a number of cell-types, including
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
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