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方案
>99% (LPS; may contain up to 10% of the 2-LPS isomer, TLC)
表单
powder
包装
pkg of 1 × 10 mg (850092P-10mg)
pkg of 1 × 5 mg (850092P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850092P
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C24H48NO9P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)32-18-21(26)19-33-35(30,31)34-20-22(25)24(28)29;/h21-22,26H,2-20,25H2,1H3,(H,28,29)(H,30,31);/q;+1/p-1/t21-,22+;/m1./s1
InChI key
SVSJEWKLQKWQOV-NSLUPJTDSA-M
一般描述
Lyso-phosphatidylserine (lyso-PS) is produced by the enzymatic action of phospholipase A1 and A2 on phosphatidylserine.
应用
Brain Lyso PS is suitable for use:
- as standard to quantify lipids using ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
- in the preparation of liposomes for coating dynabeads for binding of factor H (fH)
- as a ligand for G-protein coupled receptor 34 (GPR34) in in vitro experiments to investigate its effect granulosa cells(GC) and hormone production
- as substrate for sicariid phospholipase D (PLD) toxins (SicTox) enzymes
生化/生理作用
Lyso-Phosphatidylserine (Lyso-PS) plays a key role in histamine release from mast cells. Lyso-PS inhibits the growth to T cells. It is a chemotactic substance for fibroblast and tumor cells. Lyso-PS is involved in tumor progression and allergic reactions.
包装
5 mL Amber Glass Screw Cap Vial (850092P-10mg)
5 mL Amber Glass Screw Cap Vial (850092P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway
Iida Y, et al.
Anticancer Research, 34(10), 5465-5472 (2014)
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells
Leffler J, et al.
Test, 285(6), 3766-3776 (2010)
G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
Spicer LJ, et al.
Domestic Animal Endocrinology, 59(6), 90-99 (2017)
Altered immune response in mice deficient for the G protein-coupled receptor GPR34
Liebscher I, et al.
Test, 286(3), 2101-2110 (2011)
Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(3), 140-148 (2015)
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