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方案
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
表单
powder
包装
pkg of 1 × 10 mg (850090P-10mg)
pkg of 1 × 5 mg (850090P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850090P
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C25H49O12P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)35-16-18(26)17-36-38(33,34)37-25-23(31)21(29)20(28)22(30)24(25)32;/h18,20-26,28-32H,2-17H2,1H3,(H,33,34);/q;+1/p-1/t18-,20-,21-,22+,23-,24-,25-;/m1./s1
InChI key
CPTWBHNULFRGAT-OGIGPNSJSA-M
应用
大豆Lyso PI或L-α-溶血磷脂酰肌醇（大豆）（钠盐）已用于：
- 在巨大的单层囊泡（GUVs）中，测量LysoPI对膜弯曲刚度的效应
- 作为外源性溶血磷脂来研究其对网格蛋白依赖性内吞作用的效应
- 作为测量两种重组小鼠GDE4和GDE7蛋白的甘油磷酸二酯磷酸二酯酶（GP-PDE）和溶血磷脂酶D活性的底物
生化/生理作用
溶血磷脂酰肌醇（LPI）是一种生物活性脂质，在许多生物学事件中均作为信号传导介质参与。它控制细胞生长、区分和运动。LPI与癌症细胞增殖等病理过程有关。
包装
5 mL棕色玻璃螺旋盖小瓶（850090P-10mg）
5 mL棕色玻璃螺旋盖小瓶（850090P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
动植物源性产品
Syamsul A Arifin et al.
Metabolites, 6(1) (2016-01-20)
Metabolism is a chemical process used by cells to transform food-derived nutrients, such as proteins, carbohydrates and fats, into chemical and thermal energy. Whenever an alteration of this process occurs, the chemical balance within the cells is impaired and this
Noriyasu Ohshima et al.
The Journal of biological chemistry, 290(7), 4260-4271 (2014-12-22)
The known mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) hydrolyze glycerophosphodiesters. In this study, two novel members of the mammalian GP-PDE family, GDE4 and GDE7, were isolated, and the molecular basis of mammalian GP-PDEs was further explored. The GDE4 and GDE7 sequences are
Ieva Ailte et al.
Traffic (Copenhagen, Denmark), 18(3), 176-191 (2017-01-10)
In this study, we have investigated how clathrin-dependent endocytosis is affected by exogenously added lysophospholipids (LPLs). Addition of LPLs with large head groups strongly inhibits transferrin (Tf) endocytosis in various cell lines, while LPLs with small head groups do not.
Alejandro Melero et al.
Current biology : CB, 28(12), 1950-1958 (2018-06-12)
Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange
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