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关于此项目
经验公式（希尔记法）:
C26H52NO7P
化学文摘社编号:
分子量:
521.67
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
18:1 Lyso PC, Avanti Research™ - A Croda Brand
SMILES string
O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O
InChI
1S/C26H52NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h12-13,25,28H,5-11,14-24H2,1-4H3/b13-12-/t25-/m1/s1
InChI key
YAMUFBLWGFFICM-PTGWMXDISA-N
description
1-oleoyl-2-hydroxy-sn-glycero-3-phosphocholine
assay
>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)
form
powder
packaging
pkg of 2 × 100 mg (845875P-200mg)
pkg of 5 × 100 mg (845875P-500mg)
pkg of 1 × 25 mg (845875P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Packaging
5 mL透明玻璃密封安瓿瓶(845875P-25mg)
5 mL透明玻璃密封安瓿瓶(845875P-500mg)
5 mL透明玻璃密封安瓿瓶(845875P-200mg)
Application
18：1的溶血PC适合用作溶血磷脂介质，以比较鞘氨醇磷酸胆碱（SPC）的作用。 它已被用作酵母氮基（YNB）培养基中的补充物，以挽救胆碱营养缺陷。
Biochem/physiol Actions
溶血磷脂酰胆碱（LPC）是氧化低密度脂蛋白（Ox-LDL）表现动脉粥样硬化活性的关键因素。它可改变在内皮细胞、平滑肌细胞，单核细胞、巨噬细胞、T细胞中的作用，从而参与动脉粥样硬化和炎症性疾病的发生。LPC可激活蛋白激酶C、细胞外信号调节激酶、蛋白酪氨酸激酶、以及作为第二信使的Ca（2+）。
General description
溶血磷脂酰胆碱（LPC）是一种溶血磷脂介质。 这种具有生物活性的促炎脂质是通过病理活动产生的。它是氧化型低密度脂蛋白（Ox-LDL）的重要成分之一。
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
zu HDM and Jakobs KH
Biochimica et Biophysica Acta - Biomembranes, 1768(4), 923-940 (2007)
Overproduction of phospholipids by the Kennedy Pathway Leads to Hypervirulence in Candida albicans
Tams RN, et al.
Frontiers in Microbiology, 10(2), 86-86 (2019)
Regulation of ryanodine receptors by sphingosylphosphorylcholine: Involvement of both calmodulin-dependent and-independent mechanisms
Kovacs E, et al.
Biochemical and biophysical research communications, 401(2), 281-286 (2010)
Jacinto López-Sagaseta et al.
The EMBO journal, 31(8), 2047-2059 (2012-03-08)
Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC) presentation by human CD1d and its recognition by
Sobhan Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(43), E4648-E4657 (2014-10-10)
CD1c is a member of the group 1 CD1 family of proteins that are specialized for lipid antigen presentation. Despite high cell surface expression of CD1c on key antigen-presenting cells and the discovery of its mycobacterial lipid antigen presentation capability
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