描述
1-oleoyl-2-hydroxy-sn-glycero-3-phosphocholine
检测方案
>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)
形式
powder
包装
pkg of 2 × 100 mg (845875P-200mg)
pkg of 5 × 100 mg (845875P-500mg)
pkg of 1 × 25 mg (845875P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O
InChI
1S/C26H52NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h12-13,25,28H,5-11,14-24H2,1-4H3/b13-12-/t25-/m1/s1
InChI key
YAMUFBLWGFFICM-PTGWMXDISA-N
一般描述
溶血磷脂酰胆碱（LPC）是一种溶血磷脂介质。 这种具有生物活性的促炎脂质是通过病理活动产生的。它是氧化型低密度脂蛋白（Ox-LDL）的重要成分之一。
应用
18：1的溶血PC适合用作溶血磷脂介质，以比较鞘氨醇磷酸胆碱（SPC）的作用。 它已被用作酵母氮基（YNB）培养基中的补充物，以挽救胆碱营养缺陷。
生化/生理作用
溶血磷脂酰胆碱（LPC）是氧化低密度脂蛋白（Ox-LDL）表现动脉粥样硬化活性的关键因素。它可改变在内皮细胞、平滑肌细胞，单核细胞、巨噬细胞、T细胞中的作用，从而参与动脉粥样硬化和炎症性疾病的发生。LPC可激活蛋白激酶C、细胞外信号调节激酶、蛋白酪氨酸激酶、以及作为第二信使的Ca（2+）。
包装
5 mL透明玻璃密封安瓿瓶(845875P-200mg)
5 mL透明玻璃密封安瓿瓶(845875P-25mg)
5 mL透明玻璃密封安瓿瓶(845875P-500mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Overproduction of phospholipids by the Kennedy Pathway Leads to Hypervirulence in Candida albicans
Tams RN, et al.
Frontiers in Microbiology, 10(2), 86-86 (2019)
Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
zu HDM and Jakobs KH
Biochimica et Biophysica Acta - Biomembranes, 1768(4), 923-940 (2007)
Regulation of ryanodine receptors by sphingosylphosphorylcholine: Involvement of both calmodulin-dependent and-independent mechanisms
Kovacs E, et al.
Biochemical and biophysical research communications, 401(2), 281-286 (2010)
Jacinto López-Sagaseta et al.
The EMBO journal, 31(8), 2047-2059 (2012-03-08)
Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC) presentation by human CD1d and its recognition by
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
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