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安全信息

840875C

Avanti

二油酰磷脂酸(18:1 PA)

Avanti Research™ - A Croda Brand

别名:

1,2-二-（9Z-十八烯酰）-sn-甘油-3-磷酸（钠盐）；DOPA；PA (18:1 (9Z)/18:1 (9Z))

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About This Item

经验公式（希尔记法）:
C39H72O8PNa
CAS号:
108392-02-5
分子量:
722.95
MDL编号:
MFCD00674303
UNSPSC代码:
51191904
NACRES:
NA.25

描述

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt), chloroform solution

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (840875C-25mg)
pkg of 2 × 20 mL (840875C-1g)
pkg of 2 × 4 mL (840875C-200mg)
pkg of 5 × 4 mL (840875C-500mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (840875C-25mg)
25 mg/mL (840875C-1g)
25 mg/mL (840875C-200mg)
25 mg/mL (840875C-500mg)

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na].[P](=O)(OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC)(O)O

InChI

1S/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17-,20-18-;/t37-;/m1./s1

InChI key

KHDHADSEKGCPKW-ZBFGHDQJSA-N

相关类别

一般描述

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）是以磷脂酸基团为骨架的修饰脂质的钠盐。

应用

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）已用于：
  • 作为磷脂酸(PA)薄层色谱(TLC)分析的合成标准品，在碘染色后确定磷脂酸位置
  • 作为脂质标准品，用于优化液相色谱−质谱 (LC-MS)分析条件
  • 作为磷脂放射性标记分析的脂质标准品

生化/生理作用

磷脂酸（PA）起脂质信使作用。它在雷帕霉素（mTOR）信号转导的哺乳动物靶标中起关键作用。

包装

30 mL带螺旋盖的琥珀色窄口玻璃瓶(840875C-1g)
5 mL透明玻璃密封安瓿(840875C-200mg)
5 mL透明玻璃密封安瓿(840875C-25mg)
5 mL透明玻璃密封安瓿(840875C-500mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

危险化学品
易制毒化学品（2类）

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout the reproductive life. Intra-oocyte PI3K/mTOR pathways have been indicated to play a central role on the activation
Kathleen Frondorf et al.
The Journal of biological chemistry, 285(21), 15837-15847 (2010-03-23)
Phosphatidic acid (PA) is a pleiotropic lipid second messenger in mammalian cells. We report here that extracellular PA acts as a leukocyte chemoattractant, as membrane-soluble dioleoyl-PA (DOPA) elicits actin polymerization and chemotaxis of human neutrophils and differentiated proleukemic HL-60 cells.
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The gut microbiota represents a huge community of microorganisms that play essential roles in immune modulation and homeostasis maintenance. Microbiota transplantation is an important approach to prevent and treat disease as it can inhibit pathogen colonization and positively modulate bacterial
Shireesha Sankella et al.
The Journal of biological chemistry, 289(8), 4762-4777 (2014-01-16)
In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). Liver lysophosphatidic acid and PA levels were increased ∼2- and
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