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Merck
CN

840875C

Avanti

二油酰磷脂酸(18:1 PA)

Avanti Research™ - A Croda Brand

别名:

1,2-二-（9Z-十八烯酰）-sn-甘油-3-磷酸（钠盐）；DOPA；PA (18:1 (9Z)/18:1 (9Z))

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关于此项目

经验公式（希尔记法）:
C39H72O8PNa
化学文摘社编号:
108392-02-5
分子量:
722.95
MDL number:
MFCD00674303
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

二油酰磷脂酸(18:1 PA), Avanti Research™ - A Croda Brand

SMILES string

[Na].[P](=O)(OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC)(O)O

InChI

1S/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17-,20-18-;/t37-;/m1./s1

InChI key

KHDHADSEKGCPKW-ZBFGHDQJSA-N

description

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt), chloroform solution

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840875C-25mg)
pkg of 2 × 20 mL (840875C-1g)
pkg of 2 × 4 mL (840875C-200mg)
pkg of 5 × 4 mL (840875C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (840875C-25mg)
25 mg/mL (840875C-1g)
25 mg/mL (840875C-200mg)
25 mg/mL (840875C-500mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）已用于：
  • 作为磷脂酸(PA)薄层色谱(TLC)分析的合成标准品，在碘染色后确定磷脂酸位置
  • 作为脂质标准品，用于优化液相色谱−质谱 (LC-MS)分析条件
  • 作为磷脂放射性标记分析的脂质标准品

Biochem/physiol Actions

磷脂酸（PA）起脂质信使作用。它在雷帕霉素（mTOR）信号转导的哺乳动物靶标中起关键作用。

General description

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）是以磷脂酸基团为骨架的修饰脂质的钠盐。

Packaging

30 mL带螺旋盖的琥珀色窄口玻璃瓶(840875C-1g)
5 mL透明玻璃密封安瓿(840875C-200mg)
5 mL透明玻璃密封安瓿(840875C-25mg)
5 mL透明玻璃密封安瓿(840875C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

危险化学品
易制毒化学品（2类）
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历史批次信息供参考:

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Shireesha Sankella et al.
The Journal of biological chemistry, 289(8), 4762-4777 (2014-01-16)
In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). Liver lysophosphatidic acid and PA levels were increased ∼2- and
Shutao Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 174, 137-142 (2013-11-28)
The poor solubility of cisplatin (CDDP) often presents a major obstacle in the formulation of CDDP in nanoparticles (NPs) by traditional methods. We have developed a novel method for synthesizing CDDP NPs taking advantage of its poor solubility. By mixing
Xinhui Sun et al.
Cell cycle (Georgetown, Tex.), 14(5), 721-731 (2015-01-16)
It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout the reproductive life. Intra-oocyte PI3K/mTOR pathways have been indicated to play a central role on the activation
Kathleen Frondorf et al.
The Journal of biological chemistry, 285(21), 15837-15847 (2010-03-23)
Phosphatidic acid (PA) is a pleiotropic lipid second messenger in mammalian cells. We report here that extracellular PA acts as a leukocyte chemoattractant, as membrane-soluble dioleoyl-PA (DOPA) elicits actin polymerization and chemotaxis of human neutrophils and differentiated proleukemic HL-60 cells.
Zhenping Cao et al.
Nature communications, 10(1), 5783-5783 (2019-12-21)
The gut microbiota represents a huge community of microorganisms that play essential roles in immune modulation and homeostasis maintenance. Microbiota transplantation is an important approach to prevent and treat disease as it can inhibit pathogen colonization and positively modulate bacterial
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