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方案
>99% (up to 15% acyl migration on lysine, TLC)
表单
powder
包装
pkg of 1 × 1 mg (840521P-1mg)
pkg of 1 × 10 mg (840521P-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 840521P
脂质类型
phospholipids
bioactive lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC(COC([C@@](CCCC[NH3+])([H])[NH3+])=O)COP(O)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-].[Cl-]
InChI
1S/C48H91N2O11P.2ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36-46(52)57-41-44(42-60-62(55,56)59-40-43(51)39-58-48(54)45(50)35-33-34-38-49)61-47(53)37-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;;/h17-20,43-45,51H,3-16,21-42,49-50H2,1-2H3,(H,55,56);2*
InChI key
QLNZUMYQGKEYKU-CIZZXKMDSA-N
一般描述
18:1赖氨酰PG/1，2-二油酰基-sn-甘油-3-[磷酸-rac-（3-赖氨酰（1-甘油））]（赖氨酰-DOPG）是合成的磷脂。它具有赖氨酸基团，添加到DOPG的末端甘油上。赖氨酰磷脂酰甘油（LPG）是一种膜脂质，主要见于革兰氏阳性细菌。它是阳离子磷脂。
应用
18:1 Lysyl PG适用于制备脂质体溶液。
生化/生理作用
葡萄球菌细胞质膜中的赖氨酰磷脂酰甘油（lysyl-PG）与对抗生素（如达托霉素和宿主防御抗菌肽）的抗性提高有关。
包装
5 mL棕色玻璃螺旋盖小瓶（840521P-1mg）
5 mL透明玻璃密封安瓿（840521P-10mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance
Kilelee E, et al.
Antimicrobial Agents and Chemotherapy, 54(10), 4476-4479 (2010)
Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide
Williamson JA, et al.
Journal of molecular biology, 393(2), 383-396 (2009)
The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions
Sohlenkamp C, et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007)
Christian Sohlenkamp et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007-11-06)
Lysyl-phosphatidylglycerol (LPG) is a well-known membrane lipid in several gram-positive bacteria but is almost unheard of in gram-negative bacteria. In Staphylococcus aureus, the gene product of mprF is responsible for LPG formation. Low pH-inducible genes, termed IpiA, have been identified
Lipid bilayer modules as determinants of K+ channel gating
Syeda R, et al.
Test, 289(7), 4233-4243 (2014)
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