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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 25 mg (840513P-25mg)
制造商/商品名称
Avanti Polar Lipids 840513P
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
InChI
1S/C41H77O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(42)46-37-39(38-48-50(44,45)47-6-3)49-41(43)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h19-22,39H,4-18,23-38H2,1-3H3,(H,44,45);/q;+1/p-1/b21-19-,22-20-;/t39-;/m1./s1
InChI key
AHVVHDCFEFPKMN-AOEFFCPUSA-M
一般描述
18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol is a sodium salt of modified lipid, wherein C-1, C-2 of glycerol is substituted with 9Z-octadecenolyl and C-3 of glycerol is substituted by phosphoethanol group. This lipid metabolite of ethanol has two oleic acid chains.
应用
18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol may be used:
- as a standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
- as a reference material in quantifying phosphatidylethanol in human blood by liquid chromatography high resolution mass spectrometry (LC−HRMS )
- to incorporate into human high density lipoprotein (HDL) particles to study its effects on the secretion of vascular endothelial growth factor (VEGF) in cultured human smooth muscle cells
生化/生理作用
Phosphatidylethanol (PEth) obtained from phosphatidylcholine in erythrocytes can acts as an important biomarker for alcohol consumption.
包装
5 mL Clear Glass Sealed Ampule (840513P-25mg)
Xiaoyu Liang et al.
Molecular psychiatry (2020-02-09)
The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is thereby vulnerable to bias. There has been an interest in developing epigenetic biomarkers for HAD that might complement clinical assessment. Because alcohol consumption has been
Marja K Liisanantti et al.
Atherosclerosis, 180(2), 263-269 (2005-05-25)
To study whether qualitative changes in high density lipoprotein (HDL) phospholipids mediate part of the advantageous effects of ethanol on atherosclerosis, we investigated whether HDL associated phosphatidylethanol (PEth) affects the secretion of vascular endothelial growth factor (VEGF) from cultured human
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted
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