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检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 2.5 mL (840512C-25mg)
pkg of 1 × 20 mL (840512C-500mg)
制造商/商品名称
Avanti Polar Lipids 840512C
浓度
10 mg/mL (840512C-25mg)
25 mg/mL (840512C-500mg)
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C37H73O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-36(38)42-33-35(34-44-46(40,41)43-6-3)45-37(39)32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h35H,4-34H2,1-3H3,(H,40,41);/q;+1/p-1/t35-;/m1./s1
InChI key
MAGNEPCJIVJZIK-RUQJKXHKSA-M
一般描述
Phosphatidylethanol (PEth) is an abnormal phospholipid found in the cellular membrane. It is spotted in the liver, skeletal muscle, brain and kidney of rat when its mainly exposed to ethanol. 16:0 Phosphatidylethanol/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) has two palmitic acid chains.
应用
16:0 Phosphatidylethanol (Peth)/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) may be used:
- as an internal standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
- as an internal standard to spike blood samples for in liquid chromatography high-resolution mass spectrometry (LC−HRMS) analysis
- as a standard in calibration curve generation and validation of ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS)
生化/生理作用
Phosphatidylethanol can be used as a biomarker in blood for chronic alcohol use.
包装
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (840512C-500mg)
5 mL Clear Glass Sealed Ampule (840512C-25mg)
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
靶器官
Liver,Kidney, Respiratory system
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
易制毒化学品（2类）
危险化学品
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Guido Viel et al.
International journal of molecular sciences, 13(11), 14788-14812 (2012-12-04)
The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through "MeSH" and "free-text" protocols in the databases
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted
Natalie Kummer et al.
Analytical and bioanalytical chemistry, 408(3), 825-838 (2015-11-26)
Phosphatidylethanol species (PEths) are promising biomarkers of alcohol consumption. Here, we report on the set-up, validation, and application of a novel UHPLC-ESI-MS/MS method for the quantification of PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 in whole blood (30 μL) and
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