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安全信息

840046X

Avanti

Brain PI(4,5)P2

Avanti Research™ - A Croda Brand

别名:

Brain PI(4,5)P2, L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), chloroform:methanol:water (20:9:1)

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About This Item

CAS号:
383907-42-4
UNSPSC代码:
12352211
NACRES:
NA.25

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (840046X-10mg)
pkg of 1 × 1 mL (840046X-1mg)
pkg of 1 × 1 mL (840046X-5mg)
pkg of 1 × 2.5 mL (840046X-25mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

1 mg/mL (840046X-1mg)
10 mg/mL (840046X-10mg)
10 mg/mL (840046X-25mg)
5 mg/mL (840046X-5mg)

脂质类型

phosphoglycerides

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

InChI

1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1

InChI key

GAIOWTITBYPFJE-JVILRMJCSA-N

相关类别

一般描述

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P2)/PIP2 is produced from phosphatidyl inositol monophosphates (PIP).

应用

Brain PI(4,5)P2 has been used in the preparation of liposomes for dynamin-catalyzed fission assay and as a constituent in the lipid mixture for dual polarisation interferometry(DPI)

生化/生理作用

Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P2) plays a key role in the early stages of vesicle formation. It functions in the recruitment of endocytic coats by binding to variety of proteins involved in endocytic trafficking. PI(4,5)P2 is hydrolysed by phospholipase C to yield the signaling molecules diacylglycerol (DAG) and phosphatidyl inositol (3,4,5) triphosphate (PI(3,4,5)P3). PI(4,5)P2 is required for the functioning of many ion channels.

包装

5 mL Clear Glass Sealed Ampule (840046X-10mg)
5 mL Clear Glass Sealed Ampule (840046X-1mg)
5 mL Clear Glass Sealed Ampule (840046X-25mg)
5 mL Clear Glass Sealed Ampule (840046X-5mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

通常也和此产品一起购买

产品编号
说明
价格

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

靶器官

Central nervous system, Eyes,Central nervous system, Liver,Kidney

储存分类代码

3 - Flammable liquids

WGK

WGK 3

法规信息

易制毒化学品（2类）
危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir.
Neumann S, et al.
Nature Protocols, 8(1), 213-213 (2013)
Examination of the Interaction between a Membrane Active Peptide and Artificial Bilayers by Dual Polarisation Interferometry.
Payne JAE, et al.
Biochimica et Biophysica Acta (2016)
Phosphatidylinositol 4, 5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol.
Kinuta M, et al.
Proceedings of the National Academy of Sciences of the USA, 99(5), 2842-2847 (2002)
Visualization of HIV-1 Gag Binding to Giant Unilamellar Vesicle (GUV) Membranes.
Olety B, et al.
Journal of Visualized Experiments, 8(113), e54293-e54293 (2016)
Phosphoinositides II: The Diverse Biological Functions (2012)
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