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Merck
CN

840012C

Avanti

Heart CA

Avanti Research™ - A Croda Brand

别名:

Cardiolipin (Heart, Bovine) (sodium salt)

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关于此项目

化学文摘社编号:
383907-10-6
MDL number:
MFCD11974098
UNSPSC Code:
12352211
NACRES:
NA.25

主要文件

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产品名称

Heart CA, Avanti Research™ - A Croda Brand

SMILES string

[Na+].[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCC\C=C/C\C=C/CCCCC)OCC(O)CO[P](=O)([O-])OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCC\C=C/C\C=C/CCCCC

InChI

1S/C81H142O17P2.2Na/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2;;/h21-28,33-40,75-77,82H,5-20,29-32,41-74H2,1-4H3,(H,87,88)(H,89,90);;/q;2*+1/p-2/b25-21-,26-22-,27-23-,28-24-,37-33-,38-34-,39-35-,40-36-;;/t76-,77-;;/m1../s1

InChI key

ZGSPNIOCEDOHGS-LBOJVHLDSA-L

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2 mL (840012C-50mg)
pkg of 1 × 2.5 mL (840012C-25mg)
pkg of 1 × 4 mL (840012C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (840012C-25mg)
25 mg/mL (840012C-100mg)
25 mg/mL (840012C-50mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Application

Heart CA has been used in the Mycobacterium lipid extraction and in β- Hexosaminidase release and calcium mobilization assays. It maybe used for liposome synthesis. It may also be used as a lipid standard for the in situ analysis and characterization of cardiolipins.

Biochem/physiol Actions

Cardiolipin is involved in maintaining the structure and function of the mitochondria. It also serves as a co-factor for stimulating mitochondrial enzymes and mediates mitochondrial apoptosis. Cardiolipin is associated with the oxidative phosphorylation system for the adenine triphosphate (ATP) synthesis in the inner membrane of the mitochondria. Deficiency of cardiolipin is associated with variation of mitochondrial membrane structure and function. It is also associated with Barth syndrome.

General description

Cardiolipin is a phospholipid found in the inner membrane of the mitochondria. It is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. It consists of two phosphatidyl residues, which are linked by a glycerol group.

Packaging

5 mL Clear Glass Sealed Ampule (840012C-100mg)
5 mL Clear Glass Sealed Ampule (840012C-25mg)
5 mL Clear Glass Sealed Ampule (840012C-50mg)

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Direct MALDI-MS analysis of cardiolipin from rat organs sections
Wang Hay-Yan J, et al.
Journal of the American Society For Mass Spectrometry, 18(3), 567-577 (2007)
Cardiolipin, the heart of mitochondrial metabolism
Houtkooper R H and Vaz F M
Cellular and Molecular Life Sciences, 65(16), 2493-2506 (2008)
Cardiolipin stabilizes respiratory chain supercomplexes
Pfeiffer K, et al.
The Journal of Biological Chemistry, 278(52), 52873-52880 (2003)
Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells
Torres-Atencio I, et al.
American Journal of Respiratory and Critical Care Medicine, 198(6), 813-816 (2018)
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification
Cole NB, et al.
Experimental Cell Research, 314(10), 2076-2089 (2008)
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