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Merck
CN

830856P

Avanti

17:0 PA

1,2-diheptadecanoyl-sn-glycero-3-phosphate (sodium salt), powder

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别名:
PA(17:0/17:0)
经验公式(希尔记法):
C37H72O8PNa
分子量:
698.93
UNSPSC代码:
51191904
NACRES:
NA.25

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 25 mg (830856P-25mg)

制造商/商品名称

Avanti Polar Lipids 830856P

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

InChI

1S/C37H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36(38)43-33-35(34-44-46(40,41)42)45-37(39)32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h35H,3-34H2,1-2H3,(H2,40,41,42);/q;+1/p-1/t35-;/m1./s1

InChI key

IAELRFKIVVBNTO-RUQJKXHKSA-M

一般描述

磷脂酸(PA)是磷脂池中的次要成分。它由两个脂肪酸和一个磷酸盐组成,并借助酯键与甘油分子共价连接。PA是细胞膜的重要组成部分。

应用

17:0 PA已用作BXD肝样品/脂质组学分析的内标和BXD血浆样品分析的内标。它可以用作内标混合物中的组分,以加标脑组织匀浆。

生化/生理作用

磷脂酸(PA)起脂质信使作用。它能增强肌肉蛋白的产生。PA也可以用作信号脂质。它在雷帕霉素(mTOR)信号转导的哺乳动物靶标中起关键作用。

包装

5 mL棕色玻璃螺旋盖小瓶(830856P-25mg)

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Sophie Ayciriex et al.
Frontiers in molecular neuroscience, 10, 211-211 (2017-07-27)
Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed that cholesterol accumulation in
Yoshibumi Shimizu et al.
Prostaglandins & other lipid mediators, 150, 106450-106450 (2020-04-17)
Cyclic phosphatidic acid (cPA) is a lysophospholipid mediator that suppresses cancer metastasis and osteoarthritis. It also has neuroprotective roles in diseases such as multiple sclerosis and delayed neuronal death following transient ischemia. In order to take advantage of the properties
Emily L Gill et al.
Journal of proteome research, 19(1), 424-431 (2019-11-13)
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the brain, as well as the degeneration of motor and nonmotor circuitries. The cause of neuronal death is currently unknown, although chronic
Pooja Jha et al.
Cell systems, 6(6), 722-733 (2018-06-18)
The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or
Guillermo Escalante et al.
Journal of the International Society of Sports Nutrition, 13, 24-24 (2016-06-09)
Phosphatidic acid (PA) is a lipid messenger that has been shown to increase muscle protein synthesis via signaling stimulation of the mammalian target of rapamycin (mTOR). MaxxTOR® (MT) is a supplement that contains PA as the main active ingredient but

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