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关于此项目
经验公式（希尔记法）:
C32H54BF2N4O8P
化学文摘社编号:
分子量:
702.57
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
TopFluor™ Lyso PA, Avanti Research™ - A Croda Brand 810280P, powder
assay
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
form
powder
packaging
pkg of 1 × 1 mg (810280P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810280P
shipped in
dry ice
storage temp.
−20°C
Application
TopFluor™ Lyso PA may be used as the chromophore and as a component in the formation of the Langmuir-Blodgett (LB) film.
Biochem/physiol Actions
Lysophosphatidic acid (LPA) is very essential in signaling. It may alter proliferation, survival, cytoskeletal changes and calcium influx. It plays a key role in neointimal formation, endothelium dysfunction, monocyte attraction and adhesion.
General description
Lysophosphatidic acid (LPA) is a water-soluble, bioactive phospholipid. It is seen in mammalian cells and tissues, including blood. LPA is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.
Packaging
5 mL Amber Glass Screw Cap Vial (810280P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Diffusional motion as a gauge of fluidity and interfacial adhesion. Supported alkylphosphonate monolayers
Baumler SM, et al.
Journal of Colloid and Interface Science, 468, 145-155 (2016)
Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
Lin ME, et al.
Prostaglandins & other lipid mediators, 91(3-4), 130-138 (2010)
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for
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