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方案
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
表单
powder
包装
pkg of 1 × 1 mg (810280P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810280P
运输
dry ice
储存温度
−20°C
一般描述
Lysophosphatidic acid (LPA) is a water-soluble, bioactive phospholipid. It is seen in mammalian cells and tissues, including blood. LPA is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.
应用
TopFluor™ Lyso PA may be used as the chromophore and as a component in the formation of the Langmuir-Blodgett (LB) film.
生化/生理作用
Lysophosphatidic acid (LPA) is very essential in signaling. It may alter proliferation, survival, cytoskeletal changes and calcium influx. It plays a key role in neointimal formation, endothelium dysfunction, monocyte attraction and adhesion.
包装
5 mL Amber Glass Screw Cap Vial (810280P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Diffusional motion as a gauge of fluidity and interfacial adhesion. Supported alkylphosphonate monolayers
Baumler SM, et al.
Journal of Colloid and Interface Science, 468, 145-155 (2016)
Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
Lin ME, et al.
Prostaglandins & other lipid mediators, 91(3-4), 130-138 (2010)
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for
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