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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 250 μg (810262P-250ug)
制造商/商品名称
Avanti Polar Lipids 810262P
运输
dry ice
储存温度
−20°C
一般描述
Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.
应用
C11 TopFluor® Ceramide may be used:
- in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
- as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
- to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy
生化/生理作用
Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.
包装
5 mL Amber Glass Screw Cap Vial (810262P-250ug)
法律信息
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
法规信息
新产品
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)
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