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方案
>99% (TLC)
表单
ethanol solution
包装
pkg of 1 × 1 mL (810258E-100ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 810258E
浓度
0.1 mg/mL (810258E-100ug)
运输
dry ice
储存温度
−20°C
一般描述
C11 TopFluor™ GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).
应用
C11 TopFluor™ GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.
生化/生理作用
Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.
包装
5 mL Amber Glass Screw Cap Vial (810258E-100ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
55.4 °F - closed cup
闪点(°C)
13.0 °C - closed cup
法规信息
危险化学品
Seiichi Tagami et al.
The Journal of biological chemistry, 277(5), 3085-3092 (2001-11-15)
Gangliosides are known as modulators of transmembrane signaling by regulating various receptor functions. We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase
Christopher Lipina et al.
FEBS letters, 589(21), 3221-3227 (2015-10-06)
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the ganglioside GM3 has been linked to pathophysiological changes associated
Anshuman Das et al.
Nature microbiology, 5(9), 1069-1078 (2020-05-27)
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is
Jason G Kay et al.
Molecular biology of the cell, 23(11), 2198-2212 (2012-04-13)
Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and blood clotting using annexin V. However, because annexins are impermeant and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use. Thus
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