所有图片(1)
别名:
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-lactosyl-β1-1′-sphingosine
经验公式（希尔记法）:
C42H69N5O16
推荐产品
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (810226P-1MG)
pkg of 1 × 250 μg (810226P-250ug)
制造商/商品名称
Avanti Polar Lipids 810226P
运输
dry ice
储存温度
−20°C
一般描述
C6-NBD Lactosyl ceramide is a commercially available fluorescent analog of compound lactosyl ceramide. Lactosyl ceramide is present on neutrophils and macrophages.
应用
C6-NBD Lactosyl Ceramide has been used in:
- lactosylceramide synthase assay as a fluorescent acceptor substrate identified using fluorescence based detector in HPLC(1)
- phospholipid labeling and fluorescence-lifetime imaging microscopy (FILM) of cell membranes(6)
生化/生理作用
Lactosyl ceramide is utilized for synthesis of various glycosphingolipids like oligoglycosylceramides and gangliosides in vertebrates. It is an important molecule involved in signaling cascades leading to phenotypic changes such as adhesion, migration, cell proliferation and angiogenesis.
包装
5 mL Amber Glass Screw Cap Vial (810226P-1MG)
5 mL Amber Glass Screw Cap Vial (810226P-250ug)
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Yasuhiro Hayashi et al.
Analytical biochemistry, 345(2), 181-186 (2005-09-06)
Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates. In this article, we report a new reliable method to determine GlcT and GalT activities using the fluorescent acceptor substrates C6-4-nitrobenzo-2-oxa-1,3-diazole (NBD)-ceramide
Ana Zarubica et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1775-1785 (2009-01-20)
The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown. We report here on the biophysical analysis in living HeLa cells of the ABCA1 lipid microenvironment at the
W I Weis et al.
Annual review of biochemistry, 65, 441-473 (1996-01-01)
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cell-cell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar
Subroto Chatterjee et al.
Biochimica et biophysica acta, 1780(3), 370-382 (2007-12-14)
Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized
F Pincet et al.
Biophysical journal, 80(3), 1354-1358 (2001-02-27)
Carbohydrate-carbohydrate interactions are rarely considered in biologically relevant situations such as cell recognition and adhesion. One Ca(2+)-mediated homotypic interaction between two Lewis(x) determinants (Le(x)) has been proposed to drive cell adhesion in murine embryogenesis. Here, we confirm the existence of
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