检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 1 mL (810222C-250ug)
pkg of 1 × 1 mg (81022C-1MG)
制造商/商品名称
Avanti Research™ - A Croda Brand 810222C
浓度
0.25 mg/mL (810222C-250ug)
运输
dry ice
储存温度
−20°C
一般描述
C6-NBD Glucosyl Ceramide is a fluorescent derivative of biologically active compound, glucosyl ceramide. Glucosyl ceramide belongs to the class of sphingolipids that are synthesized in the cis/medial-Golgi apparatus by the glycosylation of ceramide.
应用
C6-NBD Glucosyl Ceramide may be used as a substrate for glucocerebrosidase (GCase) activity assay in Drosophila melanogaster and mice.
生化/生理作用
Glucosylceramide is the precursor of different glycosphingolipids including gangliosides and sulfatides. Glucosyl ceramide is also known to be responsible for axon growth of neural cells. The accumulation of glucosyl ceramide is associated with an inherited lysosomal storage disorder, Gaucher′s disease.
包装
5 mL Amber Glass Screw Cap Vial (81022C-1MG)
5 mL Clear Glass Sealed Ampule (810222C-250ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
WGK
WGK 3
法规信息
新产品
H Zhao et al.
Cellular and molecular life sciences : CMLS, 59(4), 694-707 (2002-05-23)
Gaucher disease is an autosomal recessive trait and the most common lysosomal storage disease. The pathogenesis evolves from the diminished activity of the lysosomal hydrolase, acid beta-glucosidase and the resultant accumulation of glucosylceramide within lysosomes. The pathogenic mechanisms are poorly
A Schwarz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(9), 2929-2938 (1997-05-01)
Sphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in
Yael Pewzner-Jung et al.
The Journal of biological chemistry, 285(14), 10902-10910 (2010-01-30)
Ceramide is an important lipid signaling molecule that plays critical roles in regulating cell behavior. Ceramide synthesis is surprisingly complex and is orchestrated by six mammalian ceramide synthases, each of which produces ceramides with restricted acyl chain lengths. We have
Leonardo Astudillo et al.
Biochimie, 125, 267-280 (2015-11-20)
Sphingolipids represent a major class of lipids that are essential constituents of eukaryotic cells. They are predominantly located in plasma membrane microdomains, and play an important structural role in regulating membrane fluidity. They are also bioactive effectors involved in diverse
Or Cabasso et al.
Journal of clinical medicine, 8(9) (2019-09-12)
Gaucher disease (GD) results from mutations in the GBA1 gene, which encodes lysosomal glucocerebrosidase (GCase). The large number of mutations known to date in the gene lead to a heterogeneous disorder, which is divided into a non-neuronopathic, type 1 GD
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