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关于此项目
经验公式（希尔记法）:
C36H63N5O7
化学文摘社编号:
分子量:
677.91
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C12-NBD Phytosphingosine, N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-phytosphingosine, powder
SMILES string
N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO
InChI
1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChI key
AERBNCYCJBRYDG-KSZLIROESA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (810215P-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810215P
shipped in
dry ice
storage temp.
−20°C
Application
C12-NBD Phytosphingosine has been used as a substrate in ceramidase activity assay to study enzyme activity.
C12-NBD phytosphingosine has been used as a substrate to assay ceramidase activity.
Biochem/physiol Actions
In vitro studies using human epidermis model shows that melanin production is prevented by phytosphingosine. Hence, it is widely used in cosmetics.
Phytosphingosine (PHS) is a sphingoid lipid molecule which is known to exhibit antimicrobial and anti-inflammatory action. PHS can has the ability to increase the production of keratinocyte differentiation marker proteins, such as transglutaminase 1 and involucrin, that are responsible for the development of cornifed envelope. PHS metabolism results in the formation of glycerophospholipids, sphingolipids and even-numbered fatty acids which mainly include palmitic acid.
General description
C12-NBD Phytosphingosine is a fluorescent derivative of the naturally occurring lipid compound, phytosphingosine which is localised in skin, kidney and intestines.
Phytosphingosine is a ceramide molecule localized to the stratum corneum.
Packaging
5 mL Amber Glass Screw Cap Vial (810215P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway
Jang EL, et al.
Journal of Dermatological Science, 87(1), 19-28 (2017)
Fluorescent and Luminescent Probes for Biological Activity (1999)
Phytosphingosine and sphingosine ceramide headgroup hydrogen bonding: structural insights through thermotropic hydrogen/deuterium exchange
Rerek ME, et al.
The Journal of Physical Chemistry B, 105(38), 9355-9362 (2001)
Hyun Kyung Choi et al.
Archives of dermatological research, 309(10), 795-803 (2017-09-25)
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably
Li-Yu Chen et al.
Nature communications, 6, 6030-6030 (2015-01-17)
Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain
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