810189P
Avanti
TopFluor™ PI(3,4,5)P3
Avanti Research™ - A Croda Brand 810189P, powder
别名:
1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)
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所有图片(2)
About This Item
经验公式（希尔记法）:
C56H108 BF2 N7O23P4
CAS号:
分子量:
1420.19
MDL编号:
UNSPSC代码:
12352211
NACRES:
NA.25
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方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))
制造商/商品名称
Avanti Research™ - A Croda Brand 810189P
运输
dry ice
储存温度
−20°C
一般描述
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor™ PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.
生化/生理作用
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor™ PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.
包装
2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Ebner M, et al.
Molecular Cell, 65(3), 416-431 (2017)
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Khuong TM, et al.
Neuron, 77(6), 1097-1108 (2013)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 125-125 (2015)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 77, 125-135 (2015)
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