产品名称
TopFluor™ TMR PI, Avanti Research™ - A Croda Brand 810188P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810188P-50ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 810188P
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
TopFluor™-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).
Application
TopFluor™ TMR PI has been used in fluorescence quenching of 1-palmitoyl-2-{12-[(7-nitro-2−1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphatidylcholine (NBD PC) in ternary mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC)/ 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine(POPE)/ soy l-α-phosphatidylinositol (PI) vesicles.
General description
Phosphatidylinositol (PI) is commonly found in animal tissues and bacteria. PI is soluble in water and chloroform/methanol. TopFluor™ TMR PI is a tetramethylrhodamine (TMR)-labeled fluorescent phospholipid.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810188P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Lipids of membranes: Chemistry, biological role and applications as drug carriers
Hatziantonioy S and Demetzos C
Studies in Natural Products Chemistry, 34, 173-202 (2008)
Yi Wen et al.
Biophysical journal, 114(11), 2630-2639 (2018-06-07)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2), is a key component of the inner leaflet of the plasma membrane in eukaryotic cells. In model membranes, PIP2 has been reported to form clusters, but whether these locally different conditions could give rise to
Reorganization of Ternary Lipid Mixtures of Nonphosphorylated Phosphatidylinositol Interacting with Angiomotin
Kimble-Hill, et al.
The Journal of Physical Chemistry B, 122(35), 8404-8415 (2018)
Ann C Kimble-Hill et al.
The journal of physical chemistry. B, 122(35), 8404-8415 (2018-06-08)
Phosphatidylinositol (PI) lipids are necessary for many cellular signaling pathways of membrane associated proteins, such as angiomotin (Amot). The Amot family regulates cellular polarity, growth, and migration. Given the low concentration of PI lipids in these membranes, it is likely
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