检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (810172P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810172P
运输
dry ice
储存温度
−20°C
一般描述
Phosphatidic acid (PA) is an anionic phospholipid with a phosphomonoester polar head group and two long hydrophobic acyl chains. It constitutes 1-4% of membrane lipids. NBD PA possess fluorescence analog, 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at sn-2 fatty acid of PA.
生化/生理作用
Phosphatidic acid (PA) serves as a parent compound to generate other phospholipids. It is a major signaling molecule in the regulation of cellular processes including cell proliferation, secretion and reproduction, cytoskeletal organization, and many more.
包装
5 mL Amber Glass Screw Cap Vial (810172P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
Karen M Henkels et al.
Oncotarget, 7(30), 47002-47017 (2016-06-04)
The intracellular concentration of the mitogen phosphatidic acid (PA) must be maintained at low levels until the need arises for cell proliferation. How temporal and spatial trafficking of PA affects its target proteins in the different cellular compartments is not
Interaction of amyloid beta-protein with anionic phospholipids: possible involvement of Lys28 and C-terminus aliphatic amino acids
Chauhan A, et al.
Neurochemical Research, 25(3), 423-429 (2000)
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