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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (810110P-1mg)
制造商/商品名称
Avanti Polar Lipids 810110P
运输
dry ice
储存温度
−20°C
InChI
1S/C25H40N4O5/c1-3-4-5-12-15-20(16-13-10-8-6-7-9-11-14-17-23(30)31)28(2)21-18-19-22(29(32)33)25-24(21)26-34-27-25/h18-20H,3-17H2,1-2H3,(H,30,31)
InChI key
SAAVELCIPHKGJE-UHFFFAOYSA-N
一般描述
12-NBD Stearate is amphipathic, nonesterifiable fluorescent fatty acid probe and is a long-chain fatty acid (LCFA) derivative.
应用
12-NBD Stearate has been used in the fluorescent labeling of omega-3 fatty acid in biomaterial films and as a ligand for fatty acid binding protein 5 (FABP5) in competitive binding based high throughput fluorescence displacement assay. It may be used a ligand fluorescence displacement assay of fatty-acid binding protein 5 (FABP5).
生化/生理作用
12-NBD Stearate incorporated in lipid droplets and is used majorly in fluorescence displacement binding studies of fatty-acid binding proteins. The sterol carrier protein-2 (SCP-2) 15-kDa isoform favours NBD Stearate transport. The uptake of NBD Stearate is regulated by fatty acid binding protein (FABP) expression regulates uptake and inhibited by filipin III.
包装
5 mL Amber Glass Screw Cap Vial (810110P-1mg)
Targeting fatty acid binding protein (FABP) anandamide transporters-a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
Berger WT, et al.
PLoS ONE, 7(12) (2012)
Lu Bai et al.
ACS infectious diseases, 6(4), 637-648 (2020-02-14)
Assembly of the bacterial cell wall requires not only the biosynthesis of cell wall components but also the transport of these metabolites to the cell exterior for assembly into polymers and membranes required for bacterial viability and virulence. LprG is
Tracking of drug release and material fate for naturally derived omega-3 fatty acid biomaterials
Faucher KM, et al.
Annals of Biomedical Engineering, 44(3), 782-792 (2016)
M T Milliano et al.
Hepatology (Baltimore, Md.), 33(2), 413-418 (2001-02-15)
The role of cytosolic fatty acid binding protein (FABP) in cellular fatty acid metabolism remains poorly defined. The intracellular movement of fatty acids is thought to be facilitated through codiffusion with FABP. Peroxisomal proliferators like clofibrate induce FABP and may
Cellular differentiation and I-FABP protein expression modulate fatty acid uptake and diffusion
Atshaves BP, et al.
American Journal of Physiology. Cell Physiology, 274(3), C633-C644 (1998)
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