检测方案
>99% (TLC)
形式
liquid
包装
pkg of 2 × 4 mL (800812C-200mg)
pkg of 1 × 5 mL (800812C-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 800812C
浓度
2 mg/mL (800812C-10mg)
25 mg/mL (800812C-200mg)
脂质类型
neutral lipids
neutral glycerides
运输
dry ice
储存温度
−20°C
InChI
1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1
InChI key
OQQOAWVKVDAJOI-VWLOTQADSA-N
一般描述
sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.
应用
12:0 DG may be used:
- as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis.
- as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies
- as standard in reverse-phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples
生化/生理作用
sn-1,2-Diacylglycerols are prime regulators of biological functions, especially in platelets. They also activate protein kinase C. 1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD).
包装
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-200mg)
储存及稳定性
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
其他说明
Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
靶器官
Central nervous system, Liver,Kidney
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
Exogenous sn-1, 2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
Lapetina EG, et al.
The Journal of Biological Chemistry, 260(3), 1358-1361 (1985)
Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm
Callender HL, et al.
Analytical Chemistry, 79(1), 263-272 (2007)
Lipid Profile Characterization and Lipoprotein Comparison of Extracellular Vesicles from Human Plasma and Serum
Sun Y, et al.
Metabolites, 9(11), 259-259 (2019)
Serum lipidome analysis of healthy beagle dogs receiving different diets
Boretti FS, et al.
Metabolomics, 16(1), 1-1 (2020)
Li Yang et al.
Analytical and bioanalytical chemistry, 412(10), 2225-2235 (2020-01-07)
A novel online two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography-triple-quadrupole mass spectrometry (2D SFC/RPLC-QQQ MS) method based on a vacuum solvent evaporation interface was developed for lipid profiling in human plasma, in which lipid classes were separated by the first-dimension SFC
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