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经验公式（希尔记法）:
C20H39NO4
化学文摘社编号:
分子量:
357.53
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
N-16:0 L-Serine MeEster, N-palmitoyl L-serine methyl ester, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (800730P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 800730P
lipid type
phosphoglycerides
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
N-palmitoyl-L-serine methyl ester hydrochloride is used for the synthesis of N-palmitoyl-O-phosphocholine serine (PPCS), which is a prime lipid biomarker in Niemann-Pick disease type C1. It is also used for preparation of amino acid based gelators for drug delivery studies.
General description
N-palmitoyl-L-serine methyl ester is an amino acid amphiphile. It is synthesized synthetically from N-succinimidyl palmitate, L-serine methyl ester hydrochloride and triethyl amine.
Packaging
5 mL Amber Glass Screw Cap Vial (800730P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
D Vollhardt et al.
Physical chemistry chemical physics : PCCP, 21(1), 96-103 (2018-12-07)
The monolayers of N-alkanoyl substituted threonine amphiphiles, similar to those of other N-alkanoyl-substituted amino acid amphiphiles, point to substantial differences in the main characteristics compared to usual amphiphilic monolayers. π-A measurements of the enantiomeric and racemic forms of N-alkanoyl-substituted threonine
N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease
Sidhu R, et al.
Journal of Lipid Research, 60(8), 1410-1424 (2019)
Systematic modifications of amino acid-based organogelators for the investigation of structure-property correlations in drug delivery system
Hu B, et al.
International Journal of Pharmaceutics, 547(1-2), 637-647 (2018)
Special features of monolayer characteristics of N-alkanoyl substituted threonine amphiphiles
Vollhardt D, et al.
Physical Chemistry Chemical Physics, 21(1), 96-103 (2019)
Rohini Sidhu et al.
Journal of lipid research, 60(8), 1410-1424 (2019-06-16)
Niemann-Pick disease type C1 (NPC1) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, there is an urgency to improve diagnostics and monitor therapeutic efficacy with biomarkers. In this study, we sought to define the structure
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