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Merck
CN

791268P

Avanti

DTPA-BSA (Gd)

DTPA-bis(stearylamide) (gadolinium salt), powder

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别名:
(二亚乙基三胺五乙酸)-双(硬脂酰胺)(gd盐); Gd-DTPA-BSA
经验公式(希尔记法):
C50H94GdN5O8
分子量:
1050.56
UNSPSC代码:
12352211
NACRES:
NA.25

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 100 mg (791268P-100mg)

制造商/商品名称

Avanti Polar Lipids 791268P

运输

dry ice

储存温度

−20°C

一般描述

DTPA-BSA(Gd)(二乙烯三胺五乙酸-双(硬脂酰胺)(钆盐))是一种具有顺磁性的两亲分子。

应用

DTPA-BSA(Gd)(二乙烯三胺五乙酸-双(硬脂酰胺)(钆盐))已用于:
  • 制备非靶向(NT)钆修饰两亲性多肽胶束(PAM),用于动脉粥样硬化病变的磁共振成像(MRI)
  • 在小干扰RNA(siRNA)包埋类脂纳米粒(LLN)制备中用作MRI造影剂
  • 在顺磁性鞘脂激活蛋白C(saposin C)和二油酰磷脂酰丝氨酸(SapC-DOPS)囊泡的制备中作为MRI造影剂用于多形性胶质母细胞瘤(GBM)成像

生化/生理作用

Gd-DTPA-BSA可用作磁共振成像(MRI)造影剂,钆离子可缩短纵向弛豫时间使影像更为明亮。

包装

5 mL 棕色玻璃螺旋盖样品瓶 (791268P-100mg)

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F Jasanada et al.
Bioconjugate chemistry, 7(1), 72-81 (1996-01-01)
In order to use the LDL receptor pathway to target radionuclides to cancer sites for imaging and diagnostic purposes, a labeling procedure of LDL with 111In using the DTPA-bis(stearylamide) (L) has been developed. This bifunctional ligand is intended to be
Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine
Winter PM, et al.
Journal of Magnetic Resonance Imaging : JMRI, 41(4), 1079-1087 (2015)
Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
Luo X, et al.
Nanoscale, 9(4), 1575-1579 (2017)
Sang Pil Yoo et al.
ACS omega, 1(5), 996-1003 (2016-12-06)
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by
X Luo et al.
Nanoscale, 9(4), 1575-1579 (2017-01-10)
Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time

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