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方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 g (791056P-1g)
制造商/商品名称
Avanti Research™ - A Croda Brand 791056P
脂质类型
neutral lipids
neutral glycerides
运输
dry ice
储存温度
−20°C
一般描述
2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.
应用
2-hydroxyoleic acid (2-OHOA) is suitable for use:
- to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
- to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
- as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)
生化/生理作用
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.
包装
20 mL Clear Glass Screw Cap Vial (791056P-1g)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Silvia Terés et al.
Autophagy, 8(10), 1542-1544 (2012-08-16)
The very high mortality rate of gliomas reflects the unmet therapeutic need associated with this type of brain tumor. We have discovered that the plasma membrane fulfills a critical role in the propagation of tumorigenic signals, whereby changes in membrane
2-Hydroxyoleic acid: a new hypotensive molecule
Alemany R, et al.
Hypertension, 43(2), 249-254 (2004)
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
Alemany R
Journal of Lipid Research, 47(8), 1762-1770 (2006)
Silvia Terés et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(22), 8489-8494 (2012-05-16)
Despite recent advances in the development of new cancer therapies, the treatment options for glioma remain limited, and the survival rate of patients has changed little over the past three decades. Here, we show that 2-hydroxyoleic acid (2OHOA) induces differentiation
Victoria Llado et al.
Journal of cellular and molecular medicine, 14(3), 659-670 (2009-05-06)
Minerval is an oleic acid synthetic analogue that impairs lung cancer (A549) cell proliferation upon modulation of the plasma membrane lipid structure and subsequent regulation of protein kinase C localization and activity. However, this mechanism does not fully explain the
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