产品名称
DC-Chol/DOPE混合物, Avanti Research™ - A Croda Brand 790625P, powder
form
powder
packaging
pkg of 1 × 25 mg (790625P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 790625P
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
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Application
DC-Chol/DOPE混合物已用于：
- 制备用于铁蛋白重链1（FTH1）siRNA（小分子干扰RNA）转染研究的脂质体
- 将其与生姜衍生的纳米颗粒在colon-26细胞中的细胞毒性试验进行比较
- 作为MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四唑）测定的标准对照，以评估生姜衍生脂质囊泡的生物相容性
Biochem/physiol Actions
DC-胆固醇/二油酰磷脂酰乙醇胺（30：70，w/w）有助于治疗性小干扰RNA（siRNA）的转染。DC-Chol/DOPE脂质体本质上是阳离子、单层和球形的。它有助于改善DNA的缩合，以进行转染研究。
General description
DC-胆固醇/二油酰磷脂酰乙醇胺(DOPE)脂质复合物包含阳离子脂质DC-胆固醇和中性辅助脂质DOPE。
Packaging
5 mL透明玻璃密封安瓿（790625P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mingzhen Zhang et al.
Nanomedicine (London, England), 12(16), 1927-1943 (2017-07-01)
To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. Nanoparticles composed of edible ginger-derived lipid, termed ginger-derived lipid vehicles (GDLVs) were generated from ginger
Mingzhen Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(10), 1783-1796 (2016-08-06)
The use of nanotechnology for drug delivery has shown great promise for improving cancer treatment. However, potential toxicity, hazardous environmental effects, issues with large-scale production, and potential excessive costs are challenges that confront their further clinical applications. Here, we describe
Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this
Vagisha Ravi et al.
PloS one, 14(9), e0221952-e0221952 (2019-09-07)
Elevated expression of the iron regulatory protein, ferritin heavy chain 1 (FTH1), is increasingly being associated with high tumor grade and poor survival outcomes in glioblastoma. Glioma initiating cells (GICs), a small population of stem-like cells implicated in therapeutic resistance
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