推荐产品
形式
powder
包装
pkg of 1 × 25 mg (790625P-25mg)
制造商/商品名称
Avanti Polar Lipids 790625P
脂质类型
cationic lipids
transfection
运输
dry ice
储存温度
−20°C
正在寻找类似产品? 访问 产品对比指南
一般描述
DC-胆固醇/二油酰磷脂酰乙醇胺(DOPE)脂质复合物包含阳离子脂质DC-胆固醇和中性辅助脂质DOPE。
应用
DC-Chol/DOPE混合物已用于：
- 制备用于铁蛋白重链1（FTH1）siRNA（小分子干扰RNA）转染研究的脂质体
- 将其与生姜衍生的纳米颗粒在colon-26细胞中的细胞毒性试验进行比较
- 作为MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四唑）测定的标准对照，以评估生姜衍生脂质囊泡的生物相容性
生化/生理作用
DC-胆固醇/二油酰磷脂酰乙醇胺（30：70，w/w）有助于治疗性小干扰RNA（siRNA）的转染。DC-Chol/DOPE脂质体本质上是阳离子、单层和球形的。它有助于改善DNA的缩合，以进行转染研究。
包装
5 mL透明玻璃密封安瓿（790625P-25mg)
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mingzhen Zhang et al.
Nanomedicine (London, England), 12(16), 1927-1943 (2017-07-01)
To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. Nanoparticles composed of edible ginger-derived lipid, termed ginger-derived lipid vehicles (GDLVs) were generated from ginger
Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Mingzhen Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(10), 1783-1796 (2016-08-06)
The use of nanotechnology for drug delivery has shown great promise for improving cancer treatment. However, potential toxicity, hazardous environmental effects, issues with large-scale production, and potential excessive costs are challenges that confront their further clinical applications. Here, we describe
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this
Vagisha Ravi et al.
PloS one, 14(9), e0221952-e0221952 (2019-09-07)
Elevated expression of the iron regulatory protein, ferritin heavy chain 1 (FTH1), is increasingly being associated with high tumor grade and poor survival outcomes in glioblastoma. Glioma initiating cells (GICs), a small population of stem-like cells implicated in therapeutic resistance
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门