780201C
Avanti
18:1 PE MCC
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform
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所有图片(1)
别名:
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)
经验公式（希尔记法）:
C53H90N2NaO11P
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检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 2.5 mL (780201C-25mg)
制造商/商品名称
Avanti Polar Lipids 780201C
浓度
10 mg/mL (780201C-25mg)
运输
dry ice
储存温度
−20°C
一般描述
18:1 PE MCC (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide]) lipid comprising of phosphoethanolamine linked to two oleic acid via its phosphate group and to a maleimide group via its amino group. It is a maleimide-functionalized thiol-reactive lipid.
应用
18:1 PE MCC 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] has been used:
- in liposome preparation for cysteine coupling studies
- in nanodisc impregnation for ras sarcoma protein (K-RAS4B) tethering
- in liposome preparation for single molecule imaging
包装
5 mL Clear Glass Sealed Ampule (780201C-25mg)
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system, Liver,Kidney
WGK
WGK 3
法规信息
危险化学品
易制毒化学品（2类）
Liposome-based assays to study membrane-associated protein networks
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Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored
Jenny J Lin et al.
Biophysical journal, 118(12), 2879-2893 (2020-05-15)
The natural peptide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells at single-molecule levels when membrane-associated. This distinctive feature stems from the mechanism of TCR activation, which is thought to involve
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