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Merck
CN
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文件

安全信息

750332C

Avanti

14:0 Cardiolipin (sodium salt)

1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform

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别名:
1,1′,2,2′-tetratetradecanoyl cardiolipin (sodium salt); CL(1′-[14:0/14:0],3′-[14:0/14:0])
经验公式（希尔记法）:
C65H124Na2O17P2
CAS号:
63988-21-6
分子量:
1285.60
UNSPSC代码:
51191904
NACRES:
NA.25

检测方案

>99% (TLC)

形式

solution

包装

pkg of 1 × 2.5 mL (750332C-25mg)
pkg of 2 × 4 mL (750332C-200mg)

制造商/商品名称

Avanti Polar Lipids 750332C

浓度

10 mg/mL (750332C-25mg)
25 mg/mL (750332C-200mg)

脂质类型

phospholipids
cardiolipins

运输

dry ice

储存温度

−20°C

相关类别

一般描述

Cardiolipin, the mitochondrial-specific phospholipid, helps maintain mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and the proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy (Barth syndrome). Cardiolipin has also been shown as a signaling molecule in apoptosis.

应用

14:0 Cardiolipin (sodium salt) has been used for the mass spectrometry (MS) analysis to determine the structure of lipid A.

包装

5 mL Clear Glass Sealed Ampule (750332C-200mg)
5 mL Clear Glass Sealed Ampule (750332C-25mg)

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

WGK

WGK 3

法规信息

易制毒化学品（2类）
危险化学品

分析证书(COA)

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Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm
Yoon SH, et al.
Rapid Communications in Mass Spectrometry, 30(23), 2555-2560 (2016)
Vladimir B Ritov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 831(1-2), 63-71 (2005-12-13)
Cardiolipin is a phospholipid that is specific to the inner mitochondrial membrane and essential for numerous mitochondrial functions. Accordingly, a quantitative assay for cardiolipin can be a valuable aspect of assessing mitochondrial content and functional capacity. The current study was
Role of cardiolipin alterations in mitochondrial dysfunction and disease
Chicco AJ and Sparagna GC
American Journal of Physiology. Cell Physiology, 292(1), C33-C44 (2007)
Erum Malik et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183141-183141 (2019-12-04)
Linearized esculentin 2 EM (E2EM-lin) from the frog, Glandirana emeljanovi was highly active against Gram-positive bacteria (minimum lethal concentration ≤ 5.0 μM) and strongly α-helical in the presence of lipid mimics of their membranes (>55.0%). The N-terminal α-helical structure adopted by E2EM-lin showed
Paulina Perczyk et al.
Biochimica et biophysica acta. Biomembranes, 1862(6), 183239-183239 (2020-03-03)
Soil bacteria are decomposer organisms crucial for the biodegradation of organic pollutants, mineralization of dead organic matter and the turnover of biogenic elements. In their environment they are constantly exposed to membrane-lytic enzymes emitted to the soil by other microorganisms
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