检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 25 mg (710333P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
一般描述
Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.
Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized by de novo pathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2).
The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol.
应用
16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.
生化/生理作用
Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.
Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis.
Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.
包装
5 mL Amber Glass Screw Cap Vial (710333P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
755.6 - 820.4 °F
闪点(°C)
402 - 438 °C
Irina M Le-Deygen et al.
Chemistry and physics of lipids, 228, 104891-104891 (2020-02-15)
Most drugs besides their intended activity, express undesired side effects, including those with the engagement of cell membrane. Previously, such undesired nonspecific effects on the membrane have been shown for a number of widely used nonsteroidal anti-inflammatory drugs. In this
Cardiolipin, alpha-d-glucopyranosyl, and l-lysylcardiolipin from Gram-positive bacteria: FAB MS, monofilm and X-ray powder diffraction studies
Gutberlet T, et al.
Biochimica et Biophysica Acta - Biomembranes, 1463(2) null
Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast
Beranek A, et al.
The Journal of biological chemistry, 284(17), 11572-11578 (2009)
The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015 (2015)
Myocardial Regulation of Lipidomic Flux by Cardiolipin Synthase SETTING THE BEAT FOR BIOENERGETIC EFFICIENCY
Kiebish MA, et al.
The Journal of Biological Chemistry, 287(30), 25086-25097 (2012)
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