登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C65H132N2O17P2
化学文摘社编号:
分子量:
1275.69
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
产品名称
14:0 心磷脂（铵盐）, Avanti Research™ - A Croda Brand
description
1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (710332P-200mg)
pkg of 1 × 25 mg (710332P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
Application
14:0心磷脂（铵盐）可用于脂肽合成。
在酵母菌株高效液相色谱电喷雾电离串联质谱（HPLC-ESI-MS/MS）之前，已将14:0心磷脂（铵盐）用作稳定的同位素标记标准品。它可以用作质谱和电生理研究的脂质体制备中的内标物。
Biochem/physiol Actions
TMCL（1,1′,2,2′-四肉豆蔻酰基心磷脂）双层可用于产生多室脂质体。与Barth综合征患者相关的心磷脂代谢缺陷。具有1,2-二油酰基-sn-甘油-3-磷酸胆碱(DOPC)和胆固醇的TMCL脂质体是潜在的药物递送系统。TMCL显示温度相关的热致相变。
心磷脂参与质子摄取途径，并维持所涉及酶的结构。心磷脂维持线粒体功能、膜电位以及对线粒体内膜和其中蛋白质的结构支持。心磷脂的浓度和组成变化与病理状况有关，包括缺血、甲状腺功能减退、衰老、心力衰竭和心骨骼肌病。）心磷脂可以自然形成胶束/囊泡。
General description
14:0心磷脂或TMCL（1,1′,2,2′-四肉豆蔻酰基心磷脂）是饱和CL，在低温下以凝胶形式存在。
心磷脂是一种阴离子磷脂。14:0表示连接到甘油碳上的脂肪酰基取代基。它位于线粒体内膜。
Packaging
5 mL琥珀色玻璃螺旋盖小瓶（710332P-200 mg）
5 mL琥珀色玻璃螺旋盖小瓶（710332P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in Parkinson's disease
Tyurina YY, et al.
Free Radical Research, 49(5), 681-691 (2015)
Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41
Watson DS and Szoka FC
Vaccine, 27(34), 4672-4683 (2009)
CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System
Kar A, et al.
Testing, 11(9), e0162165-e0162165 (2016)
Assessing the effect of the lipid environment on the redox potentials of the coenzymes Q10 and Q4 using lipid monolayers made of DOPC, DMPC, TMCL, TOCL, and natural cardiolipin (nCL) on mercury
Heise N and Scholz F
Electrochemical Communications, 81, 141-144 (2017)
Anja Stulz et al.
Langmuir : the ACS journal of surfaces and colloids, 35(49), 16366-16376 (2019-11-12)
Most antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs) are thought to act by permeabilizing cell membranes. For antimicrobial therapy, selectivity for pathogens over mammalian cells is a key requirement. Understanding membrane selectivity is thus essential for designing AMPs and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持