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方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 10 mg (700172P-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C([2H])([2H])[2H])C([2H])([2H])[2H])C)(CC3)C)CC=C2C1)C
InChI key
HVYWMOMLDIMFJA-QSOBUISFSA-N
一般描述
Cholesterol-d6 is a deuterium labelled cholesterol. Ring labelled D6-cholesterol forms D6-steroidal glycoalkaloids (SGA).
Cholesterol-d6 is the deuterated cholesterol with deuteration in ring.
应用
Cholesterol-d6 is suitable for its use as a synthetic lipid standard, for cholesterol determination.
Cholesterol-d6 is used as a standard to detect cholesterol concentration using chromatography technique. It is also used to measure the percentage of cholesterol absorption by intravenously administrating into experimental animals.
Cholesterol-d6 may be used as an internal standard in
- electrospray ionization tandem mass spectrometry (ESIMS/MS)
- gas chromatography–mass spectrometry (GC-MS)
- for spiking lipid extracts from Drosophila for liquid chromatography–mass spectrometry (LC-MS)
生化/生理作用
Cholesterol-d6 rich liposomes are used in understanding the kinetics of reverse cholesterol transport in lymphatic and aorta. It is used in the generation of stratum corneum (SC) lipid model systems for deuteration based neutron diffraction studies. Use of Cholesterol-d6 as a diet supplement has enabled the understanding cholesterol metabolism in the blood brain barrier.
包装
5 mL Amber Glass Screw Cap Vial (700172P-10mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 1
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Singh K, et al.
Nature Communications, 9(1), 3425-3425 (2018)
Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Martel C, et al.
The Journal of Clinical Investigation, 123(4), 1571-1579 (2013)
Perdeuteration of cholesterol for neutron scattering applications using recombinant Pichia pastoris
Moulin M, et al.
Chemistry and Physics of Lipids, 212, 80-87 (2018)
Biochemical membrane lipidomics during Drosophila development
Guan XL, et al.
Developmental Cell, 24(1), 98-111 (2013)
Localisation of partially deuterated cholesterol in quaternary SC lipid model membranes: a neutron diffraction study
Kessner D, et al.
European Biophysics Journal, 37(6), 1051-1057 (2008)
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