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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 10 mg (700172P-10mg)
制造商/商品名称
Avanti Polar Lipids 700172P
运输
dry ice
储存温度
−20°C
一般描述
Cholesterol-d6 is a deuterium labelled cholesterol. Ring labelled D6-cholesterol forms D6-steroidal glycoalkaloids (SGA).
Cholesterol-d6 is the deuterated cholesterol with deuteration in ring.
应用
Cholesterol-d6 is suitable for its use as a synthetic lipid standard, for cholesterol determination.
Cholesterol-d6 is used as a standard to detect cholesterol concentration using chromatography technique. It is also used to measure the percentage of cholesterol absorption by intravenously administrating into experimental animals.
Cholesterol-d6 may be used as an internal standard in
- electrospray ionization tandem mass spectrometry (ESIMS/MS)
- gas chromatography–mass spectrometry (GC-MS)
- for spiking lipid extracts from Drosophila for liquid chromatography–mass spectrometry (LC-MS)
生化/生理作用
Cholesterol-d6 rich liposomes are used in understanding the kinetics of reverse cholesterol transport in lymphatic and aorta. It is used in the generation of stratum corneum (SC) lipid model systems for deuteration based neutron diffraction studies. Use of Cholesterol-d6 as a diet supplement has enabled the understanding cholesterol metabolism in the blood brain barrier.
包装
5 mL Amber Glass Screw Cap Vial (700172P-10mg)
WGK
WGK 1
Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain
Saeed AA, et al.
The Journal of Biological Chemistry, 289(34), 23712-23722 (2014)
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes
Fredericks WJ, et al.
Testing, 4(7), 1075-1075 (2013)
Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue
Bonzon-Kulichenko E, et al.
Endocrinology, 150(1), 169-178 (2008)
Biochemical membrane lipidomics during Drosophila development
Guan XL, et al.
Developmental Cell, 24(1), 98-111 (2013)
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Singh K, et al.
Nature Communications, 9(1), 3425-3425 (2018)
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