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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 25 mg (700123P-25mg)
pkg of 1 × 500 mg (700123P-500mg)
制造商/商品名称
Avanti Polar Lipids 700123P
运输
dry ice
储存温度
−20°C
InChI
1S/C32H58NO4P/c1-23(2)10-9-11-24(3)28-14-15-29-27-13-12-25-22-26(37-38(34,35)36-21-20-33(6,7)8)16-18-31(25,4)30(27)17-19-32(28,29)5/h12,23-24,26-30H,9-11,13-22H2,1-8H3/p+1
InChI key
MWEZHNCHKXEIBJ-UHFFFAOYSA-O
一般描述
Ceramide forms stable, fluid bilayers with cholesteryl phosphocholine, and this formulation has been shown to be more potent than solvent-delivered (DMSO) formulations of C6 Ceramide in inhibiting proliferation, inducing apoptosis, and disturbing calcium homeostasis.CholPC forms bilayers (giant uni- and multilamellar vesicles, as well as extruded large unilamellar vesicles) with both ceramides and cholesterol. The extruded bilayers appear to be fluid, although highly ordered, even when the ceramide has an N-linked palmitoyl acyl chain.
Cholesteryl phosphocholine (CholPC) structure has hydrophobic region and a large polar head group. It takes up an umbrella structure upon interaction with lipids.
应用
Cholesteryl phosphocholine has been used in the preparation of multilamellar lipid vesicles (MLVs) for nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC) studies. It has also been used in the preparation of ceramide-cholesterol phosphocholine bilayers.
生化/生理作用
Cholesteryl phosphocholine (CholPC) is used in the generation of stable lipid bilayers. CholPC complexed to C6-ceramide is bioavailable and is useful in cell culture delivery studies. The CholPC and ceramide mixture is stable.
包装
20 mL Clear Glass Screw Cap Vial (700123P-500mg)
5 mL Amber Glass Screw Cap Vial (700123P-25mg)
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Pramod Sukumaran et al.
PloS one, 8(4), e61290-e61290 (2013-04-27)
Ceramides are potent bioactive molecules in cells. However, they are very hydrophobic molecules, and difficult to deliver efficiently to cells. We have made fluid bilayers from a short-chain D-erythro-ceramide (C6-Cer) and cholesteryl phosphocholine (CholPC), and have used this as a
Bilayer interactions among unsaturated phospholipids, sterols, and ceramide
Slotte JP, et al.
Biophysical Journal, 112(8), 1673-1681 (2017)
Max Lönnfors et al.
Langmuir : the ACS journal of surfaces and colloids, 29(7), 2319-2329 (2013-01-30)
We prepared cholesteryl phosphocholine (CholPC) by chemical synthesis and studied its interactions with small (ceramide and cholesterol) and large headgroup (sphingomyelin (SM) and phosphatidylcholine) colipids in bilayer membranes. We established that CholPC could form bilayers (giant uni- and multilamellar vesicles
Matti A Kjellberg et al.
PloS one, 10(11), e0143385-e0143385 (2015-11-26)
Ceramides can be delivered to cultured cells without solvents in the form of complexes with cholesteryl phosphocholine. We have analysed the delivery of three different radiolabeled D-erythro-ceramides (C6-Cer, C10-Cer and C16-Cer) to HeLa cells, and followed their metabolism as well
Kacee H Sims et al.
Biochimica et biophysica acta, 1841(8), 1038-1048 (2014-06-24)
Lipid research is challenging owing to the complexity and diversity of the lipidome. Here we review a set of experimental tools developed for the seasoned lipid researcher, as well as, those who are new to the field of lipid research.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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