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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (700112P-1mg)
pkg of 1 × 10 mg (700112P-10mg)
pkg of 1 × 5 mg (700112P-5mg)
制造商/商品名称
Avanti Polar Lipids 700112P
运输
dry ice
储存温度
−20°C
一般描述
7α-羟基-4-胆甾烯-3-酮是胆固醇生化合成胆汁酸的中间体。
7α-羟基-4-胆甾烯-3-酮是胆固醇生化合成胆汁酸的中间体。其前体7α-羟基胆固醇由肝脏胆固醇7α-羟化酶（CYP7A1）从胆固醇中产生。[1]它由酶7α-羟基胆甾-4-烯-3-酮12α-羟化酶代谢为7α,12α-二羟基胆甾-4-烯-3-酮，然后再代谢为胆酸，胆酸是人类主要的原胆汁酸。或者，它可以转化为5β-胆甾烷-3α,7α-二醇，然后转化为鹅去氧胆酸，这是人类的另一种主要原代胆汁酸。血清7α-羟基-4-胆甾烯-3-酮浓度反映胆汁酸合成途径的活性。血清7α-羟基-4-胆甾烯-3-酮值在白天变化，因为胆汁酸合成速率具有昼夜节律。[2] 胆汁酸吸收不良的患者中发现升高值，这可能有助于诊断这种情况，因为高值与低SeHCAT潴留有关。[3] 血清7α-羟基-4-胆甾烯-3-酮浓度的增加反映了胆汁酸吸收不良引起的胆汁酸损失，或在原发性胆汁酸腹泻中发现的合成增加，与FGF19对CYP7A1的负反馈受损有关。[4]
生化/生理作用
7α-羟基-4-胆甾烯-3-酮，由酶7α-羟基胆甾-4-烯-3-酮12α-羟化酶代谢为7α,12α-二羟基胆甾-4-烯-3-酮，然后再代谢为胆酸，胆酸是人类主要的初级胆汁酸。或者，它可以转化为5β-胆甾烷-3α,7α-二醇，然后转化为鹅去氧胆酸，这是人类的另一种主要原代胆汁酸。血清7α-羟基-4-胆甾烯-3-酮浓度反映胆汁酸合成途径的活性。血清7α-羟基-4-胆甾烯-3-酮值在白天变化，因为胆汁酸合成速率具有昼夜节律。胆汁酸吸收不良患者中测得的7α-羟基-4-胆甾烯-3-酮值升高。这可能有助于诊断这种情况，因为高值与低75硒高胆酸牛磺酸（SeHCAT）滞留有关。7α-羟基-4-胆甾烯-3-酮在伴有腹泻的肠易激综合征（IBS-D）中水平升高。氘标记的7α-羟基-4-胆甾烯-3-酮（d7-7αC4）用作液相色谱-串联质谱（LC-MS/MS）测量中的内标物。
包装
5 mL琥珀色玻璃螺旋盖样品瓶(700112P-1mg)
5 mL琥珀色玻璃螺旋盖样品瓶(700112P-5mg)
5 mL琥珀色玻璃螺旋盖样品瓶（700112P-10mg)
闪点(°F)
No data available
闪点(°C)
No data available
M Camilleri et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 21(7), 734-e43-734-e43 (2009-04-17)
Bile acid malabsorption (BAM) is reported in up to 50% of patients with functional diarrhoea and irritable bowel syndrome with diarrhoea (IBS-D). Serum 7alpha-hydroxy-4-cholesten-3-one (7alphaHCO or 7alphaC4), an indirect measurement of hepatic bile acid synthesis, has been validated as a
W Gordon Brydon et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 25(6), 319-323 (2011-07-19)
Bile acid malabsorption (BAM) is a recognized cause of watery diarrhea, often diagnosed empirically based on clinical response to cholestyramine. The radionuclide selenium-labelled homocholic acid-taurine whole body retention test is expensive, labour intensive and of limited availability. To report on
The enzymes, regulation, and genetics of bile acid synthesis. Annual review of biochemistry
Russell DW
Annual Review of Biochemistry, 72, 137-174 (2003)
Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.
Galman C, et al.
Gastroenterology, 129(5), 1445-1453 (2005)
Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.
Hofmann AF, et al.
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 7 (11), 1151-1154 (2009)
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