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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (700092P-1mg)
制造商/商品名称
Avanti Polar Lipids 700092P
运输
dry ice
储存温度
−20°C
一般描述
Campesterol-d6 is the deuterated form of campesterol. It is a plant sterol, which is an analog of cholesterol and a brassinosteroid (BR) precursor. The enzyme diminute/dwarf1 mediates the synthesis of campesterol from 24-methylenecholesterol. Campesterol possesses methyl group at C-24 position of the side chain in the cholesterol structure. It is not synthesized in mammanls and is diet derived
应用
Campesterol-d6 has been used as a deuterium-labeled internal standard in gas chromatography (GC)–triple quadrupole mass spectrometry and liquid chromatography-high resolution mass spectrometry (LC-HRMS).
生化/生理作用
Campesterol reduces the levels of chylomicron. The d6-campesterol along with d6-sitosterol and d6-cholesterol has been used in the transport blood-brain barrier studies in human brain endothelial hCMEC/D3 monolayer cells. Campesterol is a biomarker for tracking cholesterol synthesis and absorption. Campesterol like cholesterol is catabolized by intestinal microbes. It possess chemopreventive functionality prostate and breast tumors. Campesterol also has antiangiogenic property and may be useful in treating disorders related to angiogenesis.
包装
5 mL Amber Glass Screw Cap Vial (700092P-1mg)
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
美国出口管控1C298产品
S Matysik et al.
Clinical chemistry, 58(11), 1557-1564 (2012-09-22)
Cholesterol precursors and plant sterols have considerable potential as plasma biomarkers in several disorders of sterol metabolism and intestinal sterol absorption. Oxysterols are associated with atherogenesis, neurodegeneration, and inflammation. We developed a GC-MS method for the simultaneous analysis of these
Jung-Min Choi et al.
Phytotherapy research : PTR, 21(10), 954-959 (2007-07-03)
Campesterol, a plant sterol in nature, is known to have cholesterol lowering and anticarcinogenic effects. Since angiogenesis is essential for cancer, it was surmised that an antiangiogenic effect may be involved in the anticancer action of this compound. This study
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Laura Calpe-Berdiel et al.
Atherosclerosis, 203(1), 18-31 (2008-08-12)
Plant sterols and stanols (phytosterols/phytostanols) are known to reduce serum low-density lipoprotein (LDL)-cholesterol level, and food products containing these plant compounds are widely used as a therapeutic dietary option to reduce plasma cholesterol and atherosclerotic risk. The cholesterol-lowering action of
Tim Vanmierlo et al.
Journal of lipid research, 53(4), 726-735 (2012-01-27)
Plant sterols such as sitosterol and campesterol are frequently administered as cholesterol-lowering supplements in food. Recently, it has been shown in mice that, in contrast to the structurally related cholesterol, circulating plant sterols can enter the brain. We questioned whether
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