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描述
Dehydroepiandrosterone
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 g (700087P-1g)
制造商/商品名称
Avanti Polar Lipids
运输
dry ice
储存温度
−20°C
InChI
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key
FMGSKLZLMKYGDP-USOAJAOKSA-N
一般描述
25-羟基胆固醇是胆固醇的一种代谢产物。它由巨噬细胞产生。
DHEA(脱氢表雄酮)是一种由肾上腺分泌的内源性类固醇激素。DHEA是男性和女性性激素(雄激素和雌激素)的前体。
脱氢表雄酮(DHEA)是一种碳(C)-19神经活性类固醇。它由人类和哺乳动物的肾上腺合成。
生化/生理作用
25-羟基胆固醇可抑制B细胞产生IgA,并控制生发卵泡中活化B细胞的迁移。它可调节单核细胞向巨噬细胞的分化。25-羟基胆固醇在脂质的生物合成和免疫中起关键作用。它可抑制固醇调节元件结合蛋白(SREBP)的蛋白水解过程,并调节胆固醇代谢。
脱氢表雄酮(DHEA)可调节神经功能,例如神经发生、神经保护、神经元生长和分化。它可用于治疗多发性硬化症。DHEA可充当性类固醇生物合成的前体。
包装
20 mL透明玻璃螺旋盖小瓶(700087P-1g)
通常也和此产品一起购买
警示用语:
Warning
危险声明
危险分类
Repr. 2
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
25-Hydroxycholesterol: a new life in immunology
Journal of Leukocyte Biology, 88(6), 1071-1072 (2010)
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
The Journal of biological chemistry, 288(50), 35812-35823 (2013)
Sex Hormones in Neurodegenerative Processes and Diseases (2018)
Lancet (London, England), 343(8911), 1479-1481 (1994-06-11)
Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women
Molecular and cellular endocrinology, 336(1-2), 141-148 (2010-12-07)
Dehydroepiandrosterone producing adrenocortical zona reticularis and the adrenal medulla are in direct contact and are highly intermingled in many species. This results in potentially strong paracrine influences of high local dehydroepiandrosterone concentrations on the adrenal medulla. Dehydroepiandrosterone has neuroprotective properties
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