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描述
Dehydroepiandrosterone
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 g (700087P-1g)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)CC4)C)CC=C2C1)C
InChI
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key
FMGSKLZLMKYGDP-USOAJAOKSA-N
一般描述
25-羟基胆固醇是胆固醇的一种代谢产物。它由巨噬细胞产生。
DHEA（脱氢表雄酮）是一种由肾上腺分泌的内源性类固醇激素。DHEA是男性和女性性激素（雄激素和雌激素）的前体。
脱氢表雄酮（DHEA）是一种碳（C）-19神经活性类固醇。它由人类和哺乳动物的肾上腺合成。
生化/生理作用
25-羟基胆固醇可抑制B细胞产生IgA，并控制生发卵泡中活化B细胞的迁移。它可调节单核细胞向巨噬细胞的分化。25-羟基胆固醇在脂质的生物合成和免疫中起关键作用。它可抑制固醇调节元件结合蛋白（SREBP）的蛋白水解过程，并调节胆固醇代谢。
脱氢表雄酮（DHEA）可调节神经功能，例如神经发生、神经保护、神经元生长和分化。它可用于治疗多发性硬化症。DHEA可充当性类固醇生物合成的前体。
包装
20 mL透明玻璃螺旋盖小瓶（700087P-1g）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
警示用语：
Warning
危险声明
危险分类
Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Sex Hormones in Neurodegenerative Processes and Diseases (2018)
25-Hydroxycholesterol: a new life in immunology
McDonald JG and Russell DW
Journal of Leukocyte Biology, 88(6), 1071-1072 (2010)
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Shibata N, et al.
The Journal of biological chemistry, 288(50), 35812-35823 (2013)
Marco Racchi et al.
CNS drug reviews, 9(1), 21-40 (2003-02-22)
The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic
Joseph S Dillon
Current drug targets. Inflammation and allergy, 4(3), 377-385 (2005-08-17)
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in
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