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描述
(25R)-cholest-4-en-26-oic acid, 3-oxo
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (700083P-1mg)
制造商/商品名称
Avanti Polar Lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CC1(CC2)C(CCC3C1CCC4(C)C3CCC4C(CCCC(C)C(O)=O)C)=CC2=O
一般描述
3-oxo-4-cholestenoic acid (3OChA) is synthesized from cholesterol by the oxidation at the positions C3 and C26 in the presence of P450 cytochromes (CYP125 and CYP142). This pathway is well established in M. smegmatis. 3OChA is an intermediate in cholesterol catabolism and is more soluble compared to cholesterol.
应用
3-oxo-4-cholestenoic acid has been used as a inducer ligand for the TetR-like repressor (KstR) of M. smegmatis.
生化/生理作用
3-oxo-4-cholestenoic acid (3OChA) acts as an inducer to the TetR-like repressor (KstR) and modulates the expression kstR regulon genes.
包装
5 mL Amber Glass Screw Cap Vial (700083P-1mg)
Esther García-Fernández et al.
The Journal of biological chemistry, 289(25), 17576-17588 (2014-05-08)
Cholesterol degradation plays a prominent role in Mycobacterium tuberculosis infection; therefore, to develop new tools to combat this disease, we need to decipher the components comprising and regulating the corresponding pathway. A TetR-like repressor (KstR) regulates the upper part of
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