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描述
cholest-5-ene-3β,24(R)-diol
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (700071P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
一般描述
24-hydroxycholesterol (24-OH) is an oxidized product of cholesterol. It is synthesized in the presence of enzyme 24S-hydroxylase (CYP46A1).
生化/生理作用
24(S)-hydroxycholesterol is preferred over 24(R)-hydroxycholesterol by human 7α-hydroxylase. However, the porcine enzyme is active towards both isomers. 24-hydroxycholesterol (24-OH) favors sirtuin 1 expression and reduces the tau protein phosphorylation.
包装
5 mL Amber Glass Screw Cap Vial (700071P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
M Norlin et al.
Journal of lipid research, 41(10), 1629-1639 (2000-10-03)
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this oxysterol. In the
Gabriella Testa et al.
Redox biology, 17, 423-431 (2018-06-09)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to have neuroprotective
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