推荐产品
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (700070P-1mg)
制造商/商品名称
Avanti Polar Lipids
运输
dry ice
储存温度
−20°C
InChI
1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChI key
CNWPIIOQKZNXBB-VCVMUKOKSA-N
一般描述
三羟基胆甾烷酸（THCA）是胆固醇的氧化代谢产物，是胆汁酸的前体。与内质网和过氧化物酶体相关的超长链酰基辅酶A合成酶（VLCS）可激活C27胆汁酸中间体THCA。
应用
三羟基胆甾烷酸已被用作一种甾醇，以测试其与人类mincle蛋白的反应性。
生化/生理作用
观察到三羟基胆甾烷酸（THCA）和二羟基胆甾烷酸（DHCA）在齐薇格综合征和胆汁淤积性肝病中均有积累。线粒体27羟化酶有利于合成DHCA和THCA的(25R)-异构体。
包装
5 mL琥珀色玻璃螺旋盖样品瓶（700068P-1mg）
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
S Ferdinandusse et al.
Journal of lipid research, 42(1), 137-141 (2001-02-13)
We identified a new peroxisomal disorder caused by a deficiency of the enzyme alpha-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic acid (DHCA and THCA)
James O'Byrne et al.
The Journal of biological chemistry, 278(36), 34237-34244 (2003-06-18)
Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in
Ryoko Kiyotake et al.
The Journal of biological chemistry, 290(42), 25322-25332 (2015-08-25)
C-type lectin receptors (CLRs) are an emerging family of pattern recognition receptors that recognizes pathogens or damaged tissue to trigger innate immune responses. However, endogenous ligands for CLRs are not fully understood. In this study, we sought to identify an
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门