推荐产品
描述
cholest-5-ene-3β,25-diol-d6
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (700053P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
一般描述
25-羟基胆固醇（25HC）在氧气和胆固醇 25-羟化酶存在下由胆固醇合成，并且在 toll 样受体激活过程中转化依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）。25HC 分解代谢为 7α-羟基化甾醇。25-羟基胆固醇-d6 是 25-羟基胆固醇的氘代形式。
应用
25-羟基胆固醇-d6 在以下反应中用作内标：
- 通过液相色谱和串联质谱（LC-MS-MS） 法对空肠样品中的 25-OHC 进行定量
- 通过液相色谱-质谱法分析在血浆样品中
- 用于生成血浆氧甾醇定量的校准曲线
生化/生理作用
25-羟基胆固醇是一种肝脏 X 受体配体。这种生物活性脂质调节免疫反应和单核细胞的巨噬细胞产生。25-HC 作为抗病毒效应物，可能具有治疗潜力。它通过使甾醇调节元件结合蛋白失活并抑制 HMG-CoA 还原酶（HMGCR） 来减少胆固醇的生物合成。25-HC 可能通过抑制细胞凋亡和调节丝裂原活化蛋白激酶（MAPK） 通路在心肌缺血再灌注损伤中发挥保护作用。
包装
5 mL 棕色玻璃螺旋盖样品瓶（700053P-1mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
闪点(°F)
No data available
闪点(°C)
No data available
Stian Solheim et al.
The Journal of steroid biochemistry and molecular biology, 192, 105309-105309 (2019-02-20)
Oxysterols can contribute to proliferation of breast cancer through activation of the Estrogen Receptors, and to metastasis through activation of the Liver X Receptors. Endogenous levels of both esterified and free sidechain-hydroxylated oxysterols were examined in breast cancer tumours from
Elizabeth S Gold et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10666-10671 (2014-07-06)
Cross-talk between sterol regulatory pathways and inflammatory pathways has been demonstrated to significantly impact the development of both atherosclerosis and infectious disease. The oxysterol 25-hydroxycholesterol (25HC) plays multiple roles in lipid biosynthesis and immunity. We recently used a systems biology
Editorial: 25-Hydroxycholesterol: a new life in immunology.
Jeffrey G McDonald et al.
Journal of leukocyte biology, 88(6), 1071-1072 (2010-12-03)
Ying Liu et al.
Journal of lipid research, 59(3), 439-451 (2018-01-05)
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes. However, the mechanisms regulating CH25H expression have not been fully elucidated. In this study, we determined that CH25H is
Pallavi Mukherjee et al.
Journal of lipid research, 58(8), 1636-1647 (2017-06-09)
Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all P < 0.0001). WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门