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形式
powder
包装
pkg of 1 × 1 mg (700039P-1mg)
pkg of 1 × 5 mg (700039P-5mg)
制造商/商品名称
Avanti Polar Lipids
运输
dry ice
储存温度
−20°C
InChI
1S/C27H44O2/c1-17(6-11-24-25(2,3)29-24)21-9-10-22-20-8-7-18-16-19(28)12-14-26(18,4)23(20)13-15-27(21,22)5/h7,17,19-24,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,24+,26+,27-/m1/s1
InChI key
OSENKJZWYQXHBN-XVYZBDJZSA-N
一般描述
24(S),25-epoxycholesterol is an oxysterol, which is produced by fibroblasts, macrophages and brain cells.
24(S),25-epoxycholesterol is a cholesterol-derived oxysterol, which is produced by fibroblasts, macrophages, and the brain cells. 24(S),25-epoxycholesterol is synthesized de novo in the mevalonate pathway.
应用
24(S),25-epoxycholesterol has been used as an oxysterol/internalstandard to study the effects of AY9944-induced changes in neurospheres.
生化/生理作用
Exogenous addition of 24(S),25-epoxycholesterol lowers 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase activity, represses sterol regulatory element-binding protein (SREBP) processing, and induces liver × receptor (LXR) -gene targets in vitro.
包装
5 mL Amber Glass Screw Cap Vial (700039P-1mg)
5 mL Amber Glass Screw Cap Vial (700039P-5mg)
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