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描述
cholest-5-ene-3β,4β-diol
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 10 mg (700036P-10mg)
pkg of 1 × 5 mg (700036P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
OC1CCC2(C3C(C4C(C(CC4)C(CCCC(C)C)C)(CC3)C)CC=C2C1O)C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3
InChI key
CZDKQKOAHAICSF-UHFFFAOYSA-N
一般描述
4β-羟基胆固醇是一种内源性氧化固醇，由细胞色素P450 3A (CYP3A4)和CYP3A5催化形成。
生化/生理作用
4β-羟基胆固醇可充当细胞色素P450 3A (CYP3A4/5)酶活性的标志物。
包装
5 mL琥珀色玻璃螺旋盖样品瓶(700036P-10mg)
5 mL琥珀色玻璃螺旋盖样品瓶(700036P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
储存分类代码
11 - Combustible Solids
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
Diczfalusy U, et al.
British Journal of Clinical Pharmacology, 67(1), 38-43 (2009)
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease
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