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描述
cholest-5-en-3β,7α-diol
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 10 mg (700034P-10mg)
pkg of 1 × 5 mg (700034P-5mg)
pkg of 1 × 50 mg (700034P-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H]1[C@H]2[C@H]3[C@@]([C@H](CC3)[C@@H](CCCC(C)C)C)(CC[C@@H]2[C@]4(CC[C@@H](CC4=C1)O)C)C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
InChI key
OYXZMSRRJOYLLO-RVOWOUOISA-N
一般描述
7a-羟基-胆固醇是一种B环取代的氧甾醇。
应用
- Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.: 本研究通过整合代谢组学、转录组学和药物流行病学的综合方法，研究了胆汁酸代谢与痴呆症之间的关系。研究结果表明，胆汁酸合成的改变可能与痴呆症的发病机制有关(Varma et al., 2021)。
包装
5 mL琥珀色玻璃螺旋盖小瓶(700034P-10mg)
5 mL琥珀色玻璃螺旋盖小瓶(700034P-50mg)
5 mL琥珀色玻璃螺旋盖小瓶(700034P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease
Mustafa Yalcinkaya et al.
Journal of lipid research, 61(4), 492-504 (2020-01-08)
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as
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