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描述
cholestanol, 5β,6β-epoxy
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 5 mg (700033P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
C[C@]12CC[C@H]([C@](CC[C@H](O)C3)(C)[C@]3(O4)[C@H]4C5)[C@@H]5[C@@H]1CC[C@@H]2[C@H](C)CCCC(C)C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,25-,26-,27-/m1/s1
InChI key
PRYIJAGAEJZDBO-DTLXENBRSA-N
一般描述
5β,6β-epoxycholestanol (5β,6β-EC) is generated by cholesterol epoxidation and is a diastereoisomer of 5α,6α-epoxycholestanol (5α,6α-EC).
应用
5β,6β-epoxycholestanol may be used as a oxy-mix component in treating human colorectal adenocarcinoma CaCo-2 cells to test its effect on toll-like receptor (TLR) expression, in the preparation of langmuir monolayers for isotherm studies, as an internal standard for gas chromatography-mass spectrometry (GC–MS) chromatograms
生化/生理作用
5β,6β-epoxycholestanol (5β,6β-EC) is associated with human carotid plaques and is not down-regulated by apolipoprotein A1 (apoA-I) protein. 5,6β-EC along with 5α,6α-epoxycholesterol and other oxysterols are reported to be associated with Alzheimer′s disease. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol. 5β,6β-EC elicits cytotoxic and inflammatory properties.
包装
5 mL PTFE Vial with Screw Cap (700033P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque
Helmschrodt C, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 425, 3-8 (2013)
A dietary mixture of oxysterols induces in vitro intestinal inflammation through TLR2/4 activation: The protective effect of cocoa bean shells
Rossin D, et al.
Antioxidants, 8(6), 151-151 (2019)
Reduced condensing and ordering effects by 7-ketocholesterol and 5beta, 6beta-epoxycholesterol on DPPC monolayers
Telesford DM, et al.
Langmuir, 31(36), 9859-9869 (2015)
Gas chromatography-mass spectrometry determination of conjugated linoleic acids and cholesterol oxides and their stability in a model system
Yen TY, et al.
Analytical Biochemistry, 400(1), 130-138 (2010)
Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells
Paul A, et al.
International Journal of Molecular Sciences, 20(15), 3784-3784 (2019)
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