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描述
cholest-(25R)-5-ene-3β,27-diol
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (700021P-1mg)
pkg of 1 × 25 mg (700021P-25mg)
pkg of 1 × 5 mg (700021P-5mg)
制造商/商品名称
Avanti Polar Lipids
运输
dry ice
储存温度
−20°C
InChI
1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
FYHRJWMENCALJY-YSQMORBQSA-N
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一般描述
27-羟基胆固醇（27-HC）是由胆固醇在肝脏中的甾醇27-羟化酶作用下合成的。在0.15至0.73 μM的循环范围中，它是一种丰富的氧化甾醇。27-HC是胆汁合成的底物。
应用
27-羟基胆固醇已用于：
- 观察其对肝脏脂质积累的抑制作用
- 作为乳腺癌细胞系中的肝X受体(LXR)配体
- 作为液相色谱-串联质谱(LC-MS-MS)法中的对照，量化空肠样品中的25-OHC
生化/生理作用
27-羟基胆固醇（27-HC）是一种弱肝X受体（LXR）激动剂和选择性雌激素受体调节剂（SERM）。在高胆固醇血症中观察到了27-HC的水平升高。27-HC与乳腺癌肿瘤和胶质母细胞瘤进展有关。27-HC可能有助于治疗非酒精性脂肪性肝炎。27-HC的水平升高与动脉粥样硬化病变相关。
包装
5 mL棕色玻璃螺旋盖样品瓶（700021P-1mg）
5 mL棕色玻璃螺旋盖样品瓶（700021P-25mg）
5 mL棕色玻璃螺旋盖样品瓶（700021P-5mg）
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Marjan Shafaati et al.
Journal of lipid research, 52(5), 1004-1010 (2011-02-22)
There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a correlation between 27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass the blood-brain barrier, we
Sun-Mi Kim et al.
Toxicology and applied pharmacology, 274(3), 462-470 (2013-12-29)
Th1 lymphocytes are predominant in atherosclerotic lesions. However, mechanisms involved in the Th1 predominance are unknown. We have investigated the possibility of Th1 lymphocyte recruitment in a cholesterol-rich milieu. A high cholesterol diet resulted in enhanced expression of CCR5 ligands
Ratna Karuna et al.
Atherosclerosis, 214(2), 448-455 (2010-12-07)
Secretion of 27-hydroxycholesterol (27OHC) from macrophages is considered as an alternative to HDL-mediated reverse transport of excess cholesterol. We investigated 27OHC-concentrations in plasma of humans and mice with monogenic disorders of HDL metabolism. As compared to family controls mutations in
Qian Wu et al.
Cell reports, 5(3), 637-645 (2013-11-12)
To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, in ER+ breast cancer patients
Jacques E Rossouw et al.
Circulation, 126(13), 1577-1586 (2012-08-31)
Menopausal hormone therapy (MHT) increases the risk of coronary heart disease (CHD) in older women with elevated low-density lipoprotein (LDLC) levels. The endogenous estrogen receptor antagonist 27-hydroxycholesterol (27OHC) is correlated with LDLC levels and may block the beneficial effects of
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