描述
cholesterol 3-sulfate (sodium salt)
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 g (700016P-1g)
pkg of 1 × 25 mg (700016P-25mg)
pkg of 1 × 500 mg (700016P-500mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 700016P
运输
dry ice
储存温度
−20°C
InChI
1S/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1
InChI key
LMPVQXVJTZWENW-KPNWGBFJSA-M
一般描述
胆固醇硫酸酯是在胆固醇硫转移酶存在下，由胆固醇的硫酸结合作用而合成的。它可存在于大脑、肺、头发和皮肤组织以及红细胞、血小板和精子等细胞中。
应用
胆固醇硫酸酯已被用于制备胶束以及表面等离子体共振（SPR）研究。
生化/生理作用
胆固醇硫酸酯与动脉粥样硬化病变有关，可作为血小板粘附的一种基质。它可稳定精子膜和红细胞。胆固醇硫酸酯可参与到角质细胞的分化，并在隐性X连锁鱼鳞病中水平上升。它可作为视黄酸相关孤儿受体α（RORα）的一种配体。胆固醇硫酸酯可调节葡萄糖代谢，是代谢紊乱的一个潜在靶点。它还是人类宫颈癌组织和前列腺癌的一种潜在标志物。
包装
20 mL 透明玻璃螺旋盖小瓶（700016P-1g）
20 mL 透明玻璃螺旋盖小瓶（700016P-500mg）
5 mL 琥珀色玻璃螺旋盖小瓶 (700016P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Patrizia Lopalco et al.
Frontiers in physiology, 10, 1344-1344 (2019-11-19)
The reduction of sperm motility and count, or oligoasthenozoospermia, is one of the major causes of reduced fertility or infertility in men. Lipid composition of spermatozoa is important in determining their functional characteristics, in particular on motility, acrosomal exocytosis or
Charles A Strott et al.
Journal of lipid research, 44(7), 1268-1278 (2003-05-06)
Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Although these sulfolipids have similar production and
M Merten et al.
Circulation, 103(16), 2032-2034 (2001-04-25)
Cholesterol 3-sulfate is present on a variety of cells and in human LDL, and it has been found in atherosclerotic lesions of human aorta. Its precise biological role has not yet been described. In this study, we investigated the interaction
Rebecca A Shapiro et al.
Journal of the American Chemical Society, 132(33), 11406-11407 (2010-08-06)
Doping DMPC/DHPC bicelles with cholesterol sulfate broadens the temperature range over which stable alignment occurs, forming an aligned phase at lower temperatures even with high lipid concentrations. Cholesterol sulfate appears to combine the advantages of cholesterol with those of charged
Alexey V Kostarnoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2758-E2765 (2017-03-16)
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation;
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