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Merck
CN

700014P

Avanti

5β,6β-epoxycholestanol-d7

Avanti Polar Lipids

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别名:
111115
经验公式(希尔记法):
C27H39O2D7
分子量:
409.70
UNSPSC代码:
12352100
NACRES:
NA.25

描述

cholestanol, 5β,6β-epoxy-d7

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 1 mg (700014P-1mg)

制造商/商品名称

Avanti Polar Lipids

运输

dry ice

储存温度

−20°C

一般描述

5β,6β-epoxycholestanol-d7 is the deuterated version of 5β,6β-epoxycholestanol. Cholestanol is a metabolite of cholesterol.

应用

5β,6β-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis to quantify sterol and oxysterol from mitochondrial samples. It has also been used as an oxysterol standard in high-performance liquid chromatography-mass spectrometry (HPLC-MS method).

生化/生理作用

Cholestanol levels are elevated in biliary cirrhosis and in cholestasis.

包装

5 mL Amber Glass Screw Cap Vial (700014P-1mg)

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Valentin Mutemberezi et al.
Journal of neuroinflammation, 15(1), 74-74 (2018-03-11)
Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been partially studied so far. We used an
Julien Musman et al.
Biochemical pharmacology, 142, 87-95 (2017-06-25)
A major cause of cell death during myocardial ischemia-reperfusion is mitochondrial dysfunction. We previously showed that the reperfusion of an ischemic myocardium was associated with an accumulation of cholesterol into mitochondria and a concomitant strong generation of auto-oxidized oxysterols. The
Annika Mutanen et al.
The American journal of clinical nutrition, 100(4), 1085-1094 (2014-08-08)
Increased serum concentrations of plant sterols, including stigmasterol, during parenteral nutrition (PN) have been linked with serum biochemical signs of intestinal failure-associated liver disease (IFALD), whereas clinical data on their correlation to histologic liver injury have been limited. We studied

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