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安全信息

330001S

Avanti

E06 单克隆抗体

E06 Mouse Monoclonal Antibody (IgM), Anti-(Oxidized Phospholipid), 1X PBS (Phosphate Buffered Saline) with 0.27 mM Na2 EDTA

别名:

E06 单克隆抗体, T15 抗体

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

方案

>95%

表单

solution

包装

pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330001S-100ug))

制造商/商品名称

Avanti Research™ - A Croda Brand 330001S

浓度

1 mg/mL (330001S-100ug)

运输

dry ice

储存温度

−70°C

一般描述

E06抗体是一种小鼠单克隆IgM天然抗体，其与氧化磷脂结合并与氧化LDL、氧化HDL以及由氧化磷脂共价修饰的蛋白质反应。每批次都经过活性验证，并提供有关上述应用的详细实验方案。E06抗体是由加利福尼亚大学圣地亚哥分校的Joseph Witztum博士通过使用载脂蛋白E敲除小鼠喂食高脂饮食七个月开发出来的。

应用

E06单抗已用作氧化损伤的检测标记。
E06抗体已被用于检测小鼠、斑马鱼、兔、猴和人的动脉粥样硬化斑块。它还能够与凋亡细胞结合，但不与活细胞结合，并且适用于多种应用，包括ELISA、免疫组织化学和蛋白质免疫印迹分析，以及用MRI体内成像技术。

包装

0.5 mL聚丙烯管，带螺旋盖（330001S-100ug）

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

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J Qin et al.
Journal of neuroscience research, 85(5), 977-984 (2007-02-17)
Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1-palmitoyl-2-(5'-oxo)valeryl-sn-glycero-3-phosphorylcholine (POVPC)], a lipid associated with
Peter Friedman et al.
The Journal of biological chemistry, 277(9), 7010-7020 (2001-12-18)
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis through a variety of pathways. The process involves nonspecific fragmentation, oxidative breakdown, and modification of the lipids and protein of LDL. The process yields a variety of bioactive
Arnab Chattopadhyay et al.
Journal of lipid research, 57(5), 832-847 (2016-03-12)
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone. Western
Sotirios Tsimikas et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(1), 175-181 (2006-11-04)
Oxidized phospholipids (OxPL) are pro-inflammatory. We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression. OxPL content was measured in plasma and
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
Schuh C, et al.
Acta Neuropathologica, 128(2), 247-266 (2014)
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