产品名称
E06 单克隆抗体, E06 Mouse Monoclonal Antibody (IgM), Anti-(Oxidized Phospholipid), 1X PBS (Phosphate Buffered Saline) with 0.27 mM Na2 EDTA
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
assay
>95%
form
solution
packaging
pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330001S-100ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 330001S
concentration
1 mg/mL (330001S-100ug)
shipped in
dry ice
storage temp.
−70°C
General description
E06抗体是一种小鼠单克隆IgM天然抗体，其与氧化磷脂结合并与氧化LDL、氧化HDL以及由氧化磷脂共价修饰的蛋白质反应。每批次都经过活性验证，并提供有关上述应用的详细实验方案。E06抗体是由加利福尼亚大学圣地亚哥分校的Joseph Witztum博士通过使用载脂蛋白E敲除小鼠喂食高脂饮食七个月开发出来的。
Application
E06单抗已用作氧化损伤的检测标记。
E06抗体已被用于检测小鼠、斑马鱼、兔、猴和人的动脉粥样硬化斑块。它还能够与凋亡细胞结合，但不与活细胞结合，并且适用于多种应用，包括ELISA、免疫组织化学和蛋白质免疫印迹分析，以及用MRI体内成像技术。
Packaging
0.5 mL聚丙烯管，带螺旋盖（330001S-100ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
Schuh C, et al.
Acta Neuropathologica, 128(2), 247-266 (2014)
Arnab Chattopadhyay et al.
Journal of lipid research, 57(5), 832-847 (2016-03-12)
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone. Western
Sotirios Tsimikas et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(1), 175-181 (2006-11-04)
Oxidized phospholipids (OxPL) are pro-inflammatory. We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression. OxPL content was measured in plasma and
S Hörkkö et al.
The Journal of clinical investigation, 103(1), 117-128 (1999-01-12)
We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies). We now demonstrate that those EO- autoantibodies that were originally selected for binding to copper-oxidized low-density lipoproteins (CuOx-LDL), also bound
J Qin et al.
Journal of neuroscience research, 85(5), 977-984 (2007-02-17)
Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1-palmitoyl-2-(5'-oxo)valeryl-sn-glycero-3-phosphorylcholine (POVPC)], a lipid associated with
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